Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and mitochondrial uncoupling, a...

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Detalles Bibliográficos
Autores principales: Rines, Amy K., Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Kouzu, Hidemichi, Shapiro, Jason, Shang, Meng, Burke, Michael A., Abdelwahid, Eltyeb, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A., Lopaschuk, Gary D., Schumacker, Paul T., Abel, E. Dale, Ardehali, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286102/
https://www.ncbi.nlm.nih.gov/pubmed/28117339
http://dx.doi.org/10.1038/ncomms14095

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