Accelerating the search for the missing proteins in the human proteome

The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while mu...

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Detalles Bibliográficos
Autores principales: Baker, Mark S., Ahn, Seong Beom, Mohamedali, Abidali, Islam, Mohammad T., Cantor, David, Verhaert, Peter D., Fanayan, Susan, Sharma, Samridhi, Nice, Edouard C., Connor, Mark, Ranganathan, Shoba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286205/
https://www.ncbi.nlm.nih.gov/pubmed/28117396
http://dx.doi.org/10.1038/ncomms14271
Descripción
Sumario:The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

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