Accelerating the search for the missing proteins in the human proteome

The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while mu...

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Autores principales: Baker, Mark S., Ahn, Seong Beom, Mohamedali, Abidali, Islam, Mohammad T., Cantor, David, Verhaert, Peter D., Fanayan, Susan, Sharma, Samridhi, Nice, Edouard C., Connor, Mark, Ranganathan, Shoba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286205/
https://www.ncbi.nlm.nih.gov/pubmed/28117396
http://dx.doi.org/10.1038/ncomms14271
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author Baker, Mark S.
Ahn, Seong Beom
Mohamedali, Abidali
Islam, Mohammad T.
Cantor, David
Verhaert, Peter D.
Fanayan, Susan
Sharma, Samridhi
Nice, Edouard C.
Connor, Mark
Ranganathan, Shoba
author_facet Baker, Mark S.
Ahn, Seong Beom
Mohamedali, Abidali
Islam, Mohammad T.
Cantor, David
Verhaert, Peter D.
Fanayan, Susan
Sharma, Samridhi
Nice, Edouard C.
Connor, Mark
Ranganathan, Shoba
author_sort Baker, Mark S.
collection PubMed
description The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.
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spelling pubmed-52862052017-02-22 Accelerating the search for the missing proteins in the human proteome Baker, Mark S. Ahn, Seong Beom Mohamedali, Abidali Islam, Mohammad T. Cantor, David Verhaert, Peter D. Fanayan, Susan Sharma, Samridhi Nice, Edouard C. Connor, Mark Ranganathan, Shoba Nat Commun Review Article The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins. Nature Publishing Group 2017-01-24 /pmc/articles/PMC5286205/ /pubmed/28117396 http://dx.doi.org/10.1038/ncomms14271 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Baker, Mark S.
Ahn, Seong Beom
Mohamedali, Abidali
Islam, Mohammad T.
Cantor, David
Verhaert, Peter D.
Fanayan, Susan
Sharma, Samridhi
Nice, Edouard C.
Connor, Mark
Ranganathan, Shoba
Accelerating the search for the missing proteins in the human proteome
title Accelerating the search for the missing proteins in the human proteome
title_full Accelerating the search for the missing proteins in the human proteome
title_fullStr Accelerating the search for the missing proteins in the human proteome
title_full_unstemmed Accelerating the search for the missing proteins in the human proteome
title_short Accelerating the search for the missing proteins in the human proteome
title_sort accelerating the search for the missing proteins in the human proteome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286205/
https://www.ncbi.nlm.nih.gov/pubmed/28117396
http://dx.doi.org/10.1038/ncomms14271
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