Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

Age‐related macular degeneration (AMD) is a major cause of blindness in the elderly population. Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory siali...

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Detalles Bibliográficos
Autores principales: Karlstetter, Marcus, Kopatz, Jens, Aslanidis, Alexander, Shahraz, Anahita, Caramoy, Albert, Linnartz‐Gerlach, Bettina, Lin, Yuchen, Lückoff, Anika, Fauser, Sascha, Düker, Katharina, Claude, Janine, Wang, Yiner, Ackermann, Johannes, Schmidt, Tobias, Hornung, Veit, Skerka, Christine, Langmann, Thomas, Neumann, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286381/
https://www.ncbi.nlm.nih.gov/pubmed/28003336
http://dx.doi.org/10.15252/emmm.201606627

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