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The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis
Aditoprim (ADP) has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in vitro antibacterial activities of ADP and its main metabolites were assayed, and the in vivo antibacterial efficacy of ADP f...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286432/ https://www.ncbi.nlm.nih.gov/pubmed/28145487 http://dx.doi.org/10.1038/srep41370 |
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author | Cheng, Guyue Xu, Yamei Zhu, Xudong Xie, Shuyu Wang, Liye Huang, Lingli Hao, Haihong Liu, Zhenli Pan, Yuanhu Chen, Dongmei Wang, Yulian Yuan, Zonghui |
author_facet | Cheng, Guyue Xu, Yamei Zhu, Xudong Xie, Shuyu Wang, Liye Huang, Lingli Hao, Haihong Liu, Zhenli Pan, Yuanhu Chen, Dongmei Wang, Yulian Yuan, Zonghui |
author_sort | Cheng, Guyue |
collection | PubMed |
description | Aditoprim (ADP) has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in vitro antibacterial activities of ADP and its main metabolites were assayed, and the in vivo antibacterial efficacy of ADP for the treatment of swine streptococcosis was evaluated. It was shown that Salmonella and Streptococcus from swine, Escherichia coli and Salmonella from chickens, E. coli, Streptococcus, Mannheimia, Pasteurella from calves, Streptococcus and Mannheimia from sheep, and E. coli, Flavobacterium columnare, Acinetobacter baumannii and Yersinia ruckeri from fishes were highly susceptible to ADP. Haemophilus parasuis from swine, Staphylococcus aureus, Aeromonas punctate, Mycobacterium tuberculosis, Streptococcus agalactiae from fishes, and Klebsiella from calves and sheep showed moderate susceptibility to ADP, whereas E. coli, Actinobacillus pleuropneumonia, Pasteurella, S. aureus, Clostridium perfringens from swine, S. aureus, C. perfringens from chickens, and S. aureus from calves were resistant to ADP. The main metabolites of ADP showed equal activity to that of their parent compound, and the prevention and therapeutic dosages of ADP recommended for swine streptococcosis were 10 and 20~40 mg/kg b.w., respectively. This study firstly showed that ADP had strong antibacterial activity and had potential to be used as a single drug in the treatment of bacterial infectious diseases. |
format | Online Article Text |
id | pubmed-5286432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52864322017-02-06 The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis Cheng, Guyue Xu, Yamei Zhu, Xudong Xie, Shuyu Wang, Liye Huang, Lingli Hao, Haihong Liu, Zhenli Pan, Yuanhu Chen, Dongmei Wang, Yulian Yuan, Zonghui Sci Rep Article Aditoprim (ADP) has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in vitro antibacterial activities of ADP and its main metabolites were assayed, and the in vivo antibacterial efficacy of ADP for the treatment of swine streptococcosis was evaluated. It was shown that Salmonella and Streptococcus from swine, Escherichia coli and Salmonella from chickens, E. coli, Streptococcus, Mannheimia, Pasteurella from calves, Streptococcus and Mannheimia from sheep, and E. coli, Flavobacterium columnare, Acinetobacter baumannii and Yersinia ruckeri from fishes were highly susceptible to ADP. Haemophilus parasuis from swine, Staphylococcus aureus, Aeromonas punctate, Mycobacterium tuberculosis, Streptococcus agalactiae from fishes, and Klebsiella from calves and sheep showed moderate susceptibility to ADP, whereas E. coli, Actinobacillus pleuropneumonia, Pasteurella, S. aureus, Clostridium perfringens from swine, S. aureus, C. perfringens from chickens, and S. aureus from calves were resistant to ADP. The main metabolites of ADP showed equal activity to that of their parent compound, and the prevention and therapeutic dosages of ADP recommended for swine streptococcosis were 10 and 20~40 mg/kg b.w., respectively. This study firstly showed that ADP had strong antibacterial activity and had potential to be used as a single drug in the treatment of bacterial infectious diseases. Nature Publishing Group 2017-02-01 /pmc/articles/PMC5286432/ /pubmed/28145487 http://dx.doi.org/10.1038/srep41370 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Cheng, Guyue Xu, Yamei Zhu, Xudong Xie, Shuyu Wang, Liye Huang, Lingli Hao, Haihong Liu, Zhenli Pan, Yuanhu Chen, Dongmei Wang, Yulian Yuan, Zonghui The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
title | The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
title_full | The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
title_fullStr | The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
title_full_unstemmed | The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
title_short | The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
title_sort | antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286432/ https://www.ncbi.nlm.nih.gov/pubmed/28145487 http://dx.doi.org/10.1038/srep41370 |
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