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Serum prealbumin and its changes over time are associated with mortality in acute kidney injury
Serum prealbumin is a clinically relevant indicator of nutritional status and inflammation in patients with acute kidney injury (AKI). This study aimed to determine whether serum prealbumin and its longitudinal changes over a week could improve the prediction of 90-day mortality in AKI patients. Thi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286447/ https://www.ncbi.nlm.nih.gov/pubmed/28145481 http://dx.doi.org/10.1038/srep41493 |
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author | Wang, Wenji Pan, Yu Tang, Xiao Hao, Guihua Xie, Yingxin Ma, Shuai Luo, Jianfeng Guo, Daqiao Ding, Feng |
author_facet | Wang, Wenji Pan, Yu Tang, Xiao Hao, Guihua Xie, Yingxin Ma, Shuai Luo, Jianfeng Guo, Daqiao Ding, Feng |
author_sort | Wang, Wenji |
collection | PubMed |
description | Serum prealbumin is a clinically relevant indicator of nutritional status and inflammation in patients with acute kidney injury (AKI). This study aimed to determine whether serum prealbumin and its longitudinal changes over a week could improve the prediction of 90-day mortality in AKI patients. This prospective cohort study included 340 adults with AKI between 2014 and 2015. There were 94 (27.6%) patient deaths within 90 days. Serum prealbumin level <10 mg/dL at the time of AKI diagnosis was associated with a 155% increased death risk ratio (adjusted hazard ratio [HR], 2.55; 95% confidence interval [CI], 1.18 to 5.49; P = 0.02). Serum prealbumin fall >4 mg/dL was also associated with 90-day mortality in adjusted Cox regression models (HR, 1.79; 95% CI, 1.06 to 3.03; P = 0.03). Compared to serum albumin, mortality-predictability of serum prealbumin (P = 0.01) and its changes (P = 0.01) were both increased. Adding prealbumin and its changes on the conventional covariates improved the prediction of progression to 90-day mortality (NRI 0.29, P = 0.04; aIDI 0.08; P = 0.03). In conclusion, serum prealbumin, and its changes were independent predictors of worse prognosis in AKI, and could be potential surrogates to better predict 90-day mortality. |
format | Online Article Text |
id | pubmed-5286447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52864472017-02-06 Serum prealbumin and its changes over time are associated with mortality in acute kidney injury Wang, Wenji Pan, Yu Tang, Xiao Hao, Guihua Xie, Yingxin Ma, Shuai Luo, Jianfeng Guo, Daqiao Ding, Feng Sci Rep Article Serum prealbumin is a clinically relevant indicator of nutritional status and inflammation in patients with acute kidney injury (AKI). This study aimed to determine whether serum prealbumin and its longitudinal changes over a week could improve the prediction of 90-day mortality in AKI patients. This prospective cohort study included 340 adults with AKI between 2014 and 2015. There were 94 (27.6%) patient deaths within 90 days. Serum prealbumin level <10 mg/dL at the time of AKI diagnosis was associated with a 155% increased death risk ratio (adjusted hazard ratio [HR], 2.55; 95% confidence interval [CI], 1.18 to 5.49; P = 0.02). Serum prealbumin fall >4 mg/dL was also associated with 90-day mortality in adjusted Cox regression models (HR, 1.79; 95% CI, 1.06 to 3.03; P = 0.03). Compared to serum albumin, mortality-predictability of serum prealbumin (P = 0.01) and its changes (P = 0.01) were both increased. Adding prealbumin and its changes on the conventional covariates improved the prediction of progression to 90-day mortality (NRI 0.29, P = 0.04; aIDI 0.08; P = 0.03). In conclusion, serum prealbumin, and its changes were independent predictors of worse prognosis in AKI, and could be potential surrogates to better predict 90-day mortality. Nature Publishing Group 2017-02-01 /pmc/articles/PMC5286447/ /pubmed/28145481 http://dx.doi.org/10.1038/srep41493 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Wang, Wenji Pan, Yu Tang, Xiao Hao, Guihua Xie, Yingxin Ma, Shuai Luo, Jianfeng Guo, Daqiao Ding, Feng Serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
title | Serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
title_full | Serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
title_fullStr | Serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
title_full_unstemmed | Serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
title_short | Serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
title_sort | serum prealbumin and its changes over time are associated with mortality in acute kidney injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286447/ https://www.ncbi.nlm.nih.gov/pubmed/28145481 http://dx.doi.org/10.1038/srep41493 |
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