Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

The efficacy of HIV pre-exposure prophylaxis (PrEP) relies on adherence and may also depend on the route of HIV acquisition. Clinical studies of systemic tenofovir disoproxil fumarate (TDF) PrEP revealed reduced efficacy in women compared to men with similar degrees of adherence. To select the most...

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Detalles Bibliográficos
Autores principales: Wahl, Angela, Ho, Phong T., Denton, Paul W., Garrett, Katy L., Hudgens, Michael G., Swartz, Glenn, O’Neill, Cynthia, Veronese, Fulvia, Kashuba, Angela D., Garcia, J. Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286499/
https://www.ncbi.nlm.nih.gov/pubmed/28145472
http://dx.doi.org/10.1038/srep41098

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