Development of a human vasopressin V(1a)-receptor antagonist from an evolutionary-related insect neuropeptide

Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary con...

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Detalles Bibliográficos
Autores principales: Di Giglio, Maria Giulia, Muttenthaler, Markus, Harpsøe, Kasper, Liutkeviciute, Zita, Keov, Peter, Eder, Thomas, Rattei, Thomas, Arrowsmith, Sarah, Wray, Susan, Marek, Ales, Elbert, Tomas, Alewood, Paul F., Gloriam, David E., Gruber, Christian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286520/
https://www.ncbi.nlm.nih.gov/pubmed/28145450
http://dx.doi.org/10.1038/srep41002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286520/
https://www.ncbi.nlm.nih.gov/pubmed/28145450
http://dx.doi.org/10.1038/srep41002

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