Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process

Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate...

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Detalles Bibliográficos
Autores principales: Choi, Jun Hyeon, Park, Sun Hong, Jung, Jae-Kyung, Cho, Won-Jea, Ahn, Byeongwoo, Yun, Cheong-Yong, Choi, Yong Pyo, Yeo, Jong Hun, Lee, Heesoon, Hong, Jin Tae, Han, Sang-Bae, Kim, Youngsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286524/
https://www.ncbi.nlm.nih.gov/pubmed/28145460
http://dx.doi.org/10.1038/srep41180

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