Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects

BACKGROUND: The CRISPR-Cas9 system is a widely utilized platform for transgenic animal production in various species, although its off-target effects should be addressed. Several applications of this tool have been proposed in model animals but remain insufficient for transgenic livestock production...

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Detalles Bibliográficos
Autores principales: Gao, Yuanpeng, Wu, Haibo, Wang, Yongsheng, Liu, Xin, Chen, Linlin, Li, Qian, Cui, Chenchen, Liu, Xu, Zhang, Jingcheng, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286826/
https://www.ncbi.nlm.nih.gov/pubmed/28143571
http://dx.doi.org/10.1186/s13059-016-1144-4

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