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Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys
BACKGROUND: Leukotriene receptor antagonists have been used to prevent virus-induced asthma exacerbations in autumn. Its efficacy, however, might differ with age and sex. OBJECTIVE: This study aimed to investigate whether pranlukast added to usual asthma therapy in Japanese children during autumn, s...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287065/ https://www.ncbi.nlm.nih.gov/pubmed/28154801 http://dx.doi.org/10.5415/apallergy.2017.7.1.10 |
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author | Morita, Yoshinori Campos Alberto, Eduardo Suzuki, Shuichi Sato, Yoshinori Hoshioka, Akira Abe, Hiroki Saito, Kimiyuki Tsubaki, Toshikazu Haraki, Mana Sawa, Akiko Nakayama, Yoshio Kojima, Hiroyuki Shigeta, Midori Yamaide, Fumiya Kohno, Yoichi Shimojo, Naoki |
author_facet | Morita, Yoshinori Campos Alberto, Eduardo Suzuki, Shuichi Sato, Yoshinori Hoshioka, Akira Abe, Hiroki Saito, Kimiyuki Tsubaki, Toshikazu Haraki, Mana Sawa, Akiko Nakayama, Yoshio Kojima, Hiroyuki Shigeta, Midori Yamaide, Fumiya Kohno, Yoichi Shimojo, Naoki |
author_sort | Morita, Yoshinori |
collection | PubMed |
description | BACKGROUND: Leukotriene receptor antagonists have been used to prevent virus-induced asthma exacerbations in autumn. Its efficacy, however, might differ with age and sex. OBJECTIVE: This study aimed to investigate whether pranlukast added to usual asthma therapy in Japanese children during autumn, season associated with the peak of asthma, reduces asthma exacerbations. It was also evaluated the effect of age and sex on pranlukast's efficacy. METHODS: A total of 121 asthmatic children aged 1 to 14 years were randomly assigned to receive regular pranlukast or not according to sex, and were divided in 2 age groups, 1–5 years and 6–14 years. The primary outcome was total asthma score calculated during 8 weeks by using a sticker calendar related to the days in which a child experienced a worsening of asthma symptoms. This open study lasted 60 days from September 15 to November 14, 2007. RESULTS: Significant differences in pranlukast efficacy were observed between sex and age groups. Boys aged 1 to 5 years had the lower total asthma score at 8 weeks (p = 0.002), and experienced fewer cold episodes (p = 0.007). There were no significant differences between pranlukast and control group in total asthma score at 8 weeks (p = 0.35), and in the days in which a child experienced a worsening of asthma symptoms (p = 0.67). CONCLUSION: There was a substantial benefit of adding pranlukast to usual therapy in asthmatic children, especially in boys aged 1 to 5 years, during autumn season. |
format | Online Article Text |
id | pubmed-5287065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-52870652017-02-02 Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys Morita, Yoshinori Campos Alberto, Eduardo Suzuki, Shuichi Sato, Yoshinori Hoshioka, Akira Abe, Hiroki Saito, Kimiyuki Tsubaki, Toshikazu Haraki, Mana Sawa, Akiko Nakayama, Yoshio Kojima, Hiroyuki Shigeta, Midori Yamaide, Fumiya Kohno, Yoichi Shimojo, Naoki Asia Pac Allergy Original Article BACKGROUND: Leukotriene receptor antagonists have been used to prevent virus-induced asthma exacerbations in autumn. Its efficacy, however, might differ with age and sex. OBJECTIVE: This study aimed to investigate whether pranlukast added to usual asthma therapy in Japanese children during autumn, season associated with the peak of asthma, reduces asthma exacerbations. It was also evaluated the effect of age and sex on pranlukast's efficacy. METHODS: A total of 121 asthmatic children aged 1 to 14 years were randomly assigned to receive regular pranlukast or not according to sex, and were divided in 2 age groups, 1–5 years and 6–14 years. The primary outcome was total asthma score calculated during 8 weeks by using a sticker calendar related to the days in which a child experienced a worsening of asthma symptoms. This open study lasted 60 days from September 15 to November 14, 2007. RESULTS: Significant differences in pranlukast efficacy were observed between sex and age groups. Boys aged 1 to 5 years had the lower total asthma score at 8 weeks (p = 0.002), and experienced fewer cold episodes (p = 0.007). There were no significant differences between pranlukast and control group in total asthma score at 8 weeks (p = 0.35), and in the days in which a child experienced a worsening of asthma symptoms (p = 0.67). CONCLUSION: There was a substantial benefit of adding pranlukast to usual therapy in asthmatic children, especially in boys aged 1 to 5 years, during autumn season. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2017-01 2017-01-26 /pmc/articles/PMC5287065/ /pubmed/28154801 http://dx.doi.org/10.5415/apallergy.2017.7.1.10 Text en Copyright © 2017. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Morita, Yoshinori Campos Alberto, Eduardo Suzuki, Shuichi Sato, Yoshinori Hoshioka, Akira Abe, Hiroki Saito, Kimiyuki Tsubaki, Toshikazu Haraki, Mana Sawa, Akiko Nakayama, Yoshio Kojima, Hiroyuki Shigeta, Midori Yamaide, Fumiya Kohno, Yoichi Shimojo, Naoki Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
title | Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
title_full | Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
title_fullStr | Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
title_full_unstemmed | Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
title_short | Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
title_sort | pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287065/ https://www.ncbi.nlm.nih.gov/pubmed/28154801 http://dx.doi.org/10.5415/apallergy.2017.7.1.10 |
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