The impact of age on Pru p 3 IgE production in Italy

BACKGROUND: Pollen allergy may be frequently associated with fruit-vegetables: the so-called pollen food syndrome. Pru p 3 is the most relevant peach allergen. Previously, it has been reported that serum specific IgE level to Pru p 3 depends on age in a limited geographic area. OBJECTIVE: This study...

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Detalles Bibliográficos
Autores principales: Ciprandi, Giorgio, De Amici, Mara, Di Martino, Maria Luisa, Barocci, Fiorella, Comite, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2017
Materias:
Hypothesis & Experience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287070/
https://www.ncbi.nlm.nih.gov/pubmed/28154805
http://dx.doi.org/10.5415/apallergy.2017.7.1.42
Descripción
Sumario:BACKGROUND: Pollen allergy may be frequently associated with fruit-vegetables: the so-called pollen food syndrome. Pru p 3 is the most relevant peach allergen. Previously, it has been reported that serum specific IgE level to Pru p 3 depends on age in a limited geographic area. OBJECTIVE: This study aimed to to test the hypothesis about the differences of Pru p 3 sensitization across Italy, mainly concerning the impact of age. METHODS: The current study was retrospective and multicentre, involving 2 labs in Northern Italy (709 subjects), 1 in Genoa (1,040 subjects), and 1 in Southern Italy (2,188 subjects). All of them referred to labs for IgE testing because of suspected food allergy. Serum IgE to Pru p 3 was assessed in all subjects. RESULTS: Sixteen point seven percent (16.7%) of subjects were sensitized to Pru p 3. Sensitization percentage sigificantly decreased over time. The serum IgE levels increased up to young adulthood and then decreased until aging. CONCLUSION: Our experience demonstrates that Pru p 3 sensitization and production are closely age-dependent phenomena.

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