Tritium-Labeled Compounds IV. d-Glucose-6-t, d-Xylose-5-t, and d-Mannitol-1-t

Methods are presented for the preparation of d-glucose-6-t, d-xylose-5-t, and d-mannitol-1-t by the reduction of suitable compounds with lithium borohydride-t in anhydrous tetrahydrofuran, followed by hydrolysis of the products. The starting materials for the reductions are, respectively, 1,2-O-isop...

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Detalles Bibliográficos
Autores principales: Isbell, Horace S., Frush, Harriet L., Moyer, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 1960
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287092/
https://www.ncbi.nlm.nih.gov/pubmed/32196176
http://dx.doi.org/10.6028/jres.064A.037
Descripción
Sumario:Methods are presented for the preparation of d-glucose-6-t, d-xylose-5-t, and d-mannitol-1-t by the reduction of suitable compounds with lithium borohydride-t in anhydrous tetrahydrofuran, followed by hydrolysis of the products. The starting materials for the reductions are, respectively, 1,2-O-isopropylidene-d-glucurono-6,3-lactone, 5-aldo-1,2-O-isopropylidene-d-xylo-pentofuranose, and 2,3:5,6-di-O-isopropylidene-d-mannofuranose. The apparatus and procedure for carrying out the reductions in a closed system are described.

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