Finding the start site: redefining the human initiator element

Transcription by RNA polymerase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS) that help direct the proper initiation of transcription. Taking advantage of recent advances in genome-wide sequencing approaches, Vo ngoc an...

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Detalles Bibliográficos
Autores principales: Kugel, Jennifer F., Goodrich, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287107/
https://www.ncbi.nlm.nih.gov/pubmed/28130343
http://dx.doi.org/10.1101/gad.295980.117
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author Kugel, Jennifer F.
Goodrich, James A.
author_facet Kugel, Jennifer F.
Goodrich, James A.
author_sort Kugel, Jennifer F.
collection PubMed
description Transcription by RNA polymerase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS) that help direct the proper initiation of transcription. Taking advantage of recent advances in genome-wide sequencing approaches, Vo ngoc and colleagues (pp. 6–11) identified transcripts with focused sites of initiation and found that many were transcribed from promoters containing a new consensus sequence for the human initiator (Inr) core promoter element.
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spelling pubmed-52871072017-07-01 Finding the start site: redefining the human initiator element Kugel, Jennifer F. Goodrich, James A. Genes Dev Outlook Transcription by RNA polymerase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS) that help direct the proper initiation of transcription. Taking advantage of recent advances in genome-wide sequencing approaches, Vo ngoc and colleagues (pp. 6–11) identified transcripts with focused sites of initiation and found that many were transcribed from promoters containing a new consensus sequence for the human initiator (Inr) core promoter element. Cold Spring Harbor Laboratory Press 2017-01-01 /pmc/articles/PMC5287107/ /pubmed/28130343 http://dx.doi.org/10.1101/gad.295980.117 Text en © 2017 Kugel and Goodrich; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Kugel, Jennifer F.
Goodrich, James A.
Finding the start site: redefining the human initiator element
title Finding the start site: redefining the human initiator element
title_full Finding the start site: redefining the human initiator element
title_fullStr Finding the start site: redefining the human initiator element
title_full_unstemmed Finding the start site: redefining the human initiator element
title_short Finding the start site: redefining the human initiator element
title_sort finding the start site: redefining the human initiator element
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287107/
https://www.ncbi.nlm.nih.gov/pubmed/28130343
http://dx.doi.org/10.1101/gad.295980.117
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