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Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing

MRP RNA is an abundant, essential noncoding RNA whose functions have been proposed in yeast but are incompletely understood in humans. Mutations in the genomic locus for MRP RNA cause pleiotropic human diseases, including cartilage hair hypoplasia (CHH). Here we applied CRISPR–Cas9 genome editing to...

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Detalles Bibliográficos
Autores principales:	Goldfarb, Katherine C., Cech, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287113/ https://www.ncbi.nlm.nih.gov/pubmed/28115465 http://dx.doi.org/10.1101/gad.286963.116

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