BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells

Women who carry a germline mutation in BRCA1 gene typically develop triple negative breast cancers (TNBC) and high grade serous ovarian cancers (HGSOC). Previously, we reported that wild type BRCA1 proteins, unlike the disease-associated mutant BRCA1 proteins to bind the sole sumo E2-conjugating enz...

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Detalles Bibliográficos
Autores principales: Xu, J, Footman, A, Qin, Y, Aysola, K, Black, S, Reddy, V, Singh, K, Grizzle, W, You, S, Moellering, D, Reddy, ES, Fu, Y, Rao, VN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287352/
https://www.ncbi.nlm.nih.gov/pubmed/28164176

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