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Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report
RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increase...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287963/ https://www.ncbi.nlm.nih.gov/pubmed/28121939 http://dx.doi.org/10.1097/MD.0000000000005948 |
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author | Clemente, Nicolò Alessandrini, Lara Vaccher, Emanuela De Paoli, Antonino Buttignol, Monica Canzonieri, Vincenzo Sopracordevole, Francesco |
author_facet | Clemente, Nicolò Alessandrini, Lara Vaccher, Emanuela De Paoli, Antonino Buttignol, Monica Canzonieri, Vincenzo Sopracordevole, Francesco |
author_sort | Clemente, Nicolò |
collection | PubMed |
description | RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract. DIAGNOSES: From 1996 to 2016, this patient was diagnosed with a high grade cervical intraepithelial neoplasia; a HR-HPV positive inguinal lymph node metastasis from clinically undetectable primary squamous cell carcinoma; a HPV-related vulvar high-grade squamous intraepithelial lesion and an invasive squamous cell carcinoma of the anus. INTERVENTIONS: All the intraepithelial and invasive lesions detected were properly treated, and subsequent follow up visits with gynecologic examination, anoscopy, pap smear and anal cytology were performed. OUTCOMES: After a recurrence of the anal cancer and a subsequent salvage surgery with abdominoperineal resection, at the last available follow up visit no sign of disease recurrence was found. LESSONS: This case stresses the importance of an accurate multidisciplinary follow-up in HIV-positive patients, including not only the routine medical, immunological, and virological evaluation, but also a periodical complete examination of the anogenital tract with cervicovaginal and anal cytology, colposcopy, high resolution anoscopy, and vulvar examination. |
format | Online Article Text |
id | pubmed-5287963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-52879632017-02-08 Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report Clemente, Nicolò Alessandrini, Lara Vaccher, Emanuela De Paoli, Antonino Buttignol, Monica Canzonieri, Vincenzo Sopracordevole, Francesco Medicine (Baltimore) 4850 RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract. DIAGNOSES: From 1996 to 2016, this patient was diagnosed with a high grade cervical intraepithelial neoplasia; a HR-HPV positive inguinal lymph node metastasis from clinically undetectable primary squamous cell carcinoma; a HPV-related vulvar high-grade squamous intraepithelial lesion and an invasive squamous cell carcinoma of the anus. INTERVENTIONS: All the intraepithelial and invasive lesions detected were properly treated, and subsequent follow up visits with gynecologic examination, anoscopy, pap smear and anal cytology were performed. OUTCOMES: After a recurrence of the anal cancer and a subsequent salvage surgery with abdominoperineal resection, at the last available follow up visit no sign of disease recurrence was found. LESSONS: This case stresses the importance of an accurate multidisciplinary follow-up in HIV-positive patients, including not only the routine medical, immunological, and virological evaluation, but also a periodical complete examination of the anogenital tract with cervicovaginal and anal cytology, colposcopy, high resolution anoscopy, and vulvar examination. 2017-01-27 /pmc/articles/PMC5287963/ /pubmed/28121939 http://dx.doi.org/10.1097/MD.0000000000005948 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4850 Clemente, Nicolò Alessandrini, Lara Vaccher, Emanuela De Paoli, Antonino Buttignol, Monica Canzonieri, Vincenzo Sopracordevole, Francesco Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report |
title | Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report |
title_full | Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report |
title_fullStr | Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report |
title_full_unstemmed | Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report |
title_short | Multiple preinvasive and invasive HPV-related lesions of the anogenital tract in a female patient with HIV infection: A case report |
title_sort | multiple preinvasive and invasive hpv-related lesions of the anogenital tract in a female patient with hiv infection: a case report |
topic | 4850 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287963/ https://www.ncbi.nlm.nih.gov/pubmed/28121939 http://dx.doi.org/10.1097/MD.0000000000005948 |
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