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Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes
Gestational hypertension (GH) and preeclampsia (PE) are characterized by an imbalance in angiogenic factors. However, the relationship among these factors with the severity of hypertensive disorders of pregnancy (HDP) and adverse outcomes are not fully elucidated. We examined whether these biomarker...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287982/ https://www.ncbi.nlm.nih.gov/pubmed/28121958 http://dx.doi.org/10.1097/MD.0000000000006005 |
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author | Leaños-Miranda, Alfredo Méndez-Aguilar, Francisco Ramírez-Valenzuela, Karla Leticia Serrano-Rodríguez, Marilyn Berumen-Lechuga, Guadalupe Molina-Pérez, Carlos José Isordia-Salas, Irma Campos-Galicia, Inova |
author_facet | Leaños-Miranda, Alfredo Méndez-Aguilar, Francisco Ramírez-Valenzuela, Karla Leticia Serrano-Rodríguez, Marilyn Berumen-Lechuga, Guadalupe Molina-Pérez, Carlos José Isordia-Salas, Irma Campos-Galicia, Inova |
author_sort | Leaños-Miranda, Alfredo |
collection | PubMed |
description | Gestational hypertension (GH) and preeclampsia (PE) are characterized by an imbalance in angiogenic factors. However, the relationship among these factors with the severity of hypertensive disorders of pregnancy (HDP) and adverse outcomes are not fully elucidated. We examined whether these biomarkers are related with the severity of HDP and adverse outcomes. Using a cross-sectional design, serum concentrations of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin were determined in 764 pregnant women: 75 healthy pregnant, 83 with mild GH (mGH), 105 with severe GH (sGH), 122 with mild PE (mPE), and 379 with severe PE (sPE). All angiogenic factors’ concentrations were significantly different (P ≤ 0.041) in HDP than in healthy pregnancy. In addition, these factors were markedly different in sPE than in mPE, sGH, or mGH (P ≤ 0.027) and in patients with sGH that in those with mPE or mGH (P < 0.05). As compared to mGH and mPE, patients with sGH and sPE had higher rates of both preterm delivery at <34 weeks of gestation and small-for-gestational age infants. Moreover, patients with sPE had higher rates of adverse maternal outcomes (P < 0.001) when compared to patients with mGH, sGH, or mPE. In all cases, levels of sFlt-1/PlGF ratio were significantly higher in patients with sGH and sPE who had adverse perinatal and maternal outcomes than in those with sGH and sPE who did not (P ≤ 0.016). Circulating concentrations of angiogenic factors appear to be suitable markers to assess the severity of GH and PE, and adverse outcomes. |
format | Online Article Text |
id | pubmed-5287982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-52879822017-02-08 Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes Leaños-Miranda, Alfredo Méndez-Aguilar, Francisco Ramírez-Valenzuela, Karla Leticia Serrano-Rodríguez, Marilyn Berumen-Lechuga, Guadalupe Molina-Pérez, Carlos José Isordia-Salas, Irma Campos-Galicia, Inova Medicine (Baltimore) 5600 Gestational hypertension (GH) and preeclampsia (PE) are characterized by an imbalance in angiogenic factors. However, the relationship among these factors with the severity of hypertensive disorders of pregnancy (HDP) and adverse outcomes are not fully elucidated. We examined whether these biomarkers are related with the severity of HDP and adverse outcomes. Using a cross-sectional design, serum concentrations of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin were determined in 764 pregnant women: 75 healthy pregnant, 83 with mild GH (mGH), 105 with severe GH (sGH), 122 with mild PE (mPE), and 379 with severe PE (sPE). All angiogenic factors’ concentrations were significantly different (P ≤ 0.041) in HDP than in healthy pregnancy. In addition, these factors were markedly different in sPE than in mPE, sGH, or mGH (P ≤ 0.027) and in patients with sGH that in those with mPE or mGH (P < 0.05). As compared to mGH and mPE, patients with sGH and sPE had higher rates of both preterm delivery at <34 weeks of gestation and small-for-gestational age infants. Moreover, patients with sPE had higher rates of adverse maternal outcomes (P < 0.001) when compared to patients with mGH, sGH, or mPE. In all cases, levels of sFlt-1/PlGF ratio were significantly higher in patients with sGH and sPE who had adverse perinatal and maternal outcomes than in those with sGH and sPE who did not (P ≤ 0.016). Circulating concentrations of angiogenic factors appear to be suitable markers to assess the severity of GH and PE, and adverse outcomes. 2017-01-27 /pmc/articles/PMC5287982/ /pubmed/28121958 http://dx.doi.org/10.1097/MD.0000000000006005 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5600 Leaños-Miranda, Alfredo Méndez-Aguilar, Francisco Ramírez-Valenzuela, Karla Leticia Serrano-Rodríguez, Marilyn Berumen-Lechuga, Guadalupe Molina-Pérez, Carlos José Isordia-Salas, Irma Campos-Galicia, Inova Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
title | Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
title_full | Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
title_fullStr | Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
title_full_unstemmed | Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
title_short | Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
title_sort | circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287982/ https://www.ncbi.nlm.nih.gov/pubmed/28121958 http://dx.doi.org/10.1097/MD.0000000000006005 |
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