Cargando…

The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging

Mammalian target of rapamycin complex 2 (mTORC2), one of two different enzymatic complexes of mTOR, regulates a diverse set of substrates including Akt. mTOR pathway is one of well-known mediators of aging process, however, its role in skin aging has not been determined. Skin aging can be induced by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Yeon Ja, Moon, Kyoung Mi, Chung, Ki Wung, Jeong, Ji Won, Park, Daeui, Kim, Dae Hyun, Yu, Byung Pal, Chung, Hae Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288141/ https://www.ncbi.nlm.nih.gov/pubmed/27486771 http://dx.doi.org/10.18632/oncotarget.10943

Ejemplares similares

Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis
por: Chung, Ki Wung, et al.
Publicado: (2017)

Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys
por: Jang, Eun Ji, et al.
Publicado: (2016)

Suppression of FoxO6 by lipopolysaccharide in aged rat liver
por: Kim, Dae Hyun, et al.
Publicado: (2015)

RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney
por: Park, Daeui, et al.
Publicado: (2016)

MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction
por: Kim, Kyung Mok, et al.
Publicado: (2017)

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
por: Li, Yujie, et al.
Publicado: (2018)

The involvement of serum exosomal miR-500-3p and miR-770-3p in aging: modulation by calorie restriction
por: Lee, Eun Kyeong, et al.
Publicado: (2017)

mTORC2 takes the longevity stAGE
por: Lamming, Dudley W.
Publicado: (2014)

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation
por: Bae, Ha Ram, et al.
Publicado: (2016)

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
por: Fernandes, Stephanie A., et al.
Publicado: (2021)

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
por: Cadena Sandoval, Marti, et al.
Publicado: (2021)

Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling
por: Deng, Huidan, et al.
Publicado: (2017)

Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift
por: Jylhävä, Juulia, et al.
Publicado: (2016)

SS31 Ameliorates age-related activation of NF-κB signaling in senile mice model, SAMP8
por: Hao, Zhi-Hua, et al.
Publicado: (2016)

The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer’s disease by the inhibitions of NF-κB/MAPK pathway and NLRP3 inflammasome
por: Lan, Zhou, et al.
Publicado: (2017)

Drosophila PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway
por: Pyo, Jung-Hoon, et al.
Publicado: (2018)

Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population
por: Li, Ning, et al.
Publicado: (2015)

PI3K/Akt promotes feedforward mTORC2 activation through IKKα
por: Dan, Han C., et al.
Publicado: (2016)

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus
por: Kim, Su-Jeong, et al.
Publicado: (2016)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells
por: Chang, Mei-Chi, et al.
Publicado: (2016)

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways
por: Fu, Cong, et al.
Publicado: (2015)

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT(1A) receptor mediated Akt/GSK-3β pathway
por: Wang, Yan-Juan, et al.
Publicado: (2016)

Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease
por: Lim, Su Min, et al.
Publicado: (2016)

Association and interaction effects of Alzheimer’s disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population
por: Lin, Eugene, et al.
Publicado: (2017)

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population
por: Lin, Eugene, et al.
Publicado: (2017)

Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity
por: Tsai, Kun-Ling, et al.
Publicado: (2017)

A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell carcinoma proliferation
por: Li, Zhipeng, et al.
Publicado: (2016)

The potential role of epigenetic modulations in BPPV maneuver exercises
por: Tsai, Kun-Ling, et al.
Publicado: (2016)

A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1
por: Senthil, Kumar K.J., et al.
Publicado: (2016)

The function of cux1 in oxidative dna damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
por: Ramdzan, Zubaidah M., et al.
Publicado: (2015)

Age-related reduction of antibody response against the human endogenous retrovirus K envelope in women
por: Kim, Hyoung Jin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hj7k0h4ge0fgdca2ijbt1vtug7