Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based “starvation” strategies in BRCA1 carriers

We hypothesized that women inheriting one germline mutation of the BRCA1 gene (“one-hit”) undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. Targeted metabolomic analysis was perfo...

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Detalles Bibliográficos
Autores principales: Cuyàs, Elisabet, Fernández-Arroyo, Salvador, Alarcón, Tomás, Lupu, Ruth, Joven, Jorge, Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288162/
https://www.ncbi.nlm.nih.gov/pubmed/27259235
http://dx.doi.org/10.18632/oncotarget.9732

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