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Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma

Serine-glycine biosynthetic pathway diverts the glycolytic intermediate 3-phosphoglycerate to synthesize serine and glycine, of which the latter was found to correlate with cancer cell proliferation. Increased de novo biosynthesis of glycine by serine hydroxymethyltransferase 2 (SHMT2) is the centra...

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Detalles Bibliográficos
Autores principales:	Woo, Chern Chiuh, Chen, Way Cherng, Teo, Xing Qi, Radda, George K., Teck Hock Lee, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288164/ https://www.ncbi.nlm.nih.gov/pubmed/27391339 http://dx.doi.org/10.18632/oncotarget.10415

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