Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies

PI3Kδ has been found to be over-expressed in B-Cell-related malignancies. Despite the clinical success of the first selective PI3Kδ inhibitor, CAL-101, inhibition of PI3Kδ itself did not show too much cytotoxic efficacy against cancer cells. One possible reason is that PI3Kδ inhibition induced autop...

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Detalles Bibliográficos
Autores principales: Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Liu, Juanjuan, Zou, Fengming, Chen, Cheng, Zhao, Zheng, Deng, Yuanxin, Wu, Hong, Qi, Ziping, Wang, Beilei, Wang, Li, Liu, Feiyang, Xu, Yunhe, Wang, Wenchao, Fernandes, Stacey M., Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Loh, Teckpeng, Griffin, James. D., Zhang, Shanchun, Weisberg, Ellen L., Zhang, Xin, Liu, Jing, Liu, Qingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288202/
https://www.ncbi.nlm.nih.gov/pubmed/27447747
http://dx.doi.org/10.18632/oncotarget.10650

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