Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling

Here we study the effects of inducible oncogenic K-Ras (G12V) expression on the polarized morphogenesis of colonic epithelial cells. We provide evidence that the autocrine production of heregulins, ligands for the ErbB3 receptor tyrosine kinase, is responsible for the hyperproliferation and aberrant...

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Detalles Bibliográficos
Autores principales: Möller, Yvonne, Morkel, Markus, Schmid, Jens, Beyes, Sven, Hendrick, Janina, Strotbek, Michaela, Riemer, Pamela, Schmid, Simone, Schmitt, Lisa C., Kontermann, Roland, Mürdter, Thomas, Schwab, Matthias, Sers, Christine, Olayioye, Monilola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288203/
https://www.ncbi.nlm.nih.gov/pubmed/27447549
http://dx.doi.org/10.18632/oncotarget.10658

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