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Prostate cancer and the unfolded protein response

The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretor...

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Detalles Bibliográficos
Autores principales: Storm, Margrethe, Sheng, Xia, Arnoldussen, Yke Jildouw, Saatcioglu, Fahri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288241/
https://www.ncbi.nlm.nih.gov/pubmed/27303918
http://dx.doi.org/10.18632/oncotarget.9912
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author Storm, Margrethe
Sheng, Xia
Arnoldussen, Yke Jildouw
Saatcioglu, Fahri
author_facet Storm, Margrethe
Sheng, Xia
Arnoldussen, Yke Jildouw
Saatcioglu, Fahri
author_sort Storm, Margrethe
collection PubMed
description The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications.
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spelling pubmed-52882412017-02-07 Prostate cancer and the unfolded protein response Storm, Margrethe Sheng, Xia Arnoldussen, Yke Jildouw Saatcioglu, Fahri Oncotarget Review The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications. Impact Journals LLC 2016-06-09 /pmc/articles/PMC5288241/ /pubmed/27303918 http://dx.doi.org/10.18632/oncotarget.9912 Text en Copyright: © 2016 Storm et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Storm, Margrethe
Sheng, Xia
Arnoldussen, Yke Jildouw
Saatcioglu, Fahri
Prostate cancer and the unfolded protein response
title Prostate cancer and the unfolded protein response
title_full Prostate cancer and the unfolded protein response
title_fullStr Prostate cancer and the unfolded protein response
title_full_unstemmed Prostate cancer and the unfolded protein response
title_short Prostate cancer and the unfolded protein response
title_sort prostate cancer and the unfolded protein response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288241/
https://www.ncbi.nlm.nih.gov/pubmed/27303918
http://dx.doi.org/10.18632/oncotarget.9912
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