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Prostate cancer and the unfolded protein response
The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288241/ https://www.ncbi.nlm.nih.gov/pubmed/27303918 http://dx.doi.org/10.18632/oncotarget.9912 |
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author | Storm, Margrethe Sheng, Xia Arnoldussen, Yke Jildouw Saatcioglu, Fahri |
author_facet | Storm, Margrethe Sheng, Xia Arnoldussen, Yke Jildouw Saatcioglu, Fahri |
author_sort | Storm, Margrethe |
collection | PubMed |
description | The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications. |
format | Online Article Text |
id | pubmed-5288241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52882412017-02-07 Prostate cancer and the unfolded protein response Storm, Margrethe Sheng, Xia Arnoldussen, Yke Jildouw Saatcioglu, Fahri Oncotarget Review The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications. Impact Journals LLC 2016-06-09 /pmc/articles/PMC5288241/ /pubmed/27303918 http://dx.doi.org/10.18632/oncotarget.9912 Text en Copyright: © 2016 Storm et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Storm, Margrethe Sheng, Xia Arnoldussen, Yke Jildouw Saatcioglu, Fahri Prostate cancer and the unfolded protein response |
title | Prostate cancer and the unfolded protein response |
title_full | Prostate cancer and the unfolded protein response |
title_fullStr | Prostate cancer and the unfolded protein response |
title_full_unstemmed | Prostate cancer and the unfolded protein response |
title_short | Prostate cancer and the unfolded protein response |
title_sort | prostate cancer and the unfolded protein response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288241/ https://www.ncbi.nlm.nih.gov/pubmed/27303918 http://dx.doi.org/10.18632/oncotarget.9912 |
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