Cargando…
Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats
Beta-amyloid (Aβ) deposition, associated neuronal apoptosis and neuroinflammation are considered as the important factors which lead to cognitive deficits in Alzheimer’s disease (AD). Icariside II (ICS II), an active flavonoid compound derived from Epimedium brevicornum Maxim, has been extensively u...
Autores principales: | Deng, Yuanyuan, Long, Long, Wang, Keke, Zhou, Jiayin, Zeng, Lingrong, He, Lianzi, Gong, Qihai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288340/ https://www.ncbi.nlm.nih.gov/pubmed/28210222 http://dx.doi.org/10.3389/fphar.2017.00039 |
Ejemplares similares
-
Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production
por: Yan, Lingli, et al.
Publicado: (2017) -
Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats
por: Yin, Caixia, et al.
Publicado: (2018) -
Icariside II: Anticancer Potential and Molecular Targets in Solid Cancers
por: Xu, Fei, et al.
Publicado: (2021) -
Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway
por: Xu, Fan, et al.
Publicado: (2020) -
Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase‐3β‐mediated activation of autophagy
por: Gao, Jianmei, et al.
Publicado: (2020)