Cargando…

Kinetics of Cytotoxic Lymphocytes Reconstitution after Induction Chemotherapy in Elderly AML Patients Reveals Progressive Recovery of Normal Phenotypic and Functional Features in NK Cells

NK cells are defective in acute myeloid leukemia (AML) at diagnosis. Here, we studied the kinetic of expression of the major activating and inhibitory receptors of NK, CD8 T, and γδ T cells in patients undergoing chemotherapy (CT) for the treatment of AML (n = 29). We showed that NK cells are the ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rey, Jérôme, Fauriat, Cyril, Kochbati, Eloïse, Orlanducci, Florence, Charbonnier, Aude, D’Incan, Evelyne, Andre, Pascale, Romagne, François, Barbarat, Bernadette, Vey, Norbert, Olive, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288405/ https://www.ncbi.nlm.nih.gov/pubmed/28210257 http://dx.doi.org/10.3389/fimmu.2017.00064

Ejemplares similares

NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML
por: Chretien, Anne-Sophie, et al.
Publicado: (2017)

Increased NK Cell Maturation in Patients with Acute Myeloid Leukemia
por: Chretien, Anne-Sophie, et al.
Publicado: (2015)

Cancer-Induced Alterations of NK-Mediated Target Recognition: Current and Investigational Pharmacological Strategies Aiming at Restoring NK-Mediated Anti-Tumor Activity
por: Chretien, Anne-Sophie, et al.
Publicado: (2014)

High-dimensional mass cytometry analysis of NK cell alterations in AML identifies a subgroup with adverse clinical outcome
por: Chretien, Anne-Sophie, et al.
Publicado: (2021)

PB1844: REAL: A RETROSPECTIVE STUDY OF THE CLINICO-BIOLOGICAL FEATURES OF ACUTE MYELOID LEUKEMIA AND MYELODYSPLASTIC SYNDROMES PATIENTS INCLUDED IN AN EARLY PHASE TRIAL AT A COMPREHENSIVE CANCER CENTER.
por: Berton, Guillaume, et al.
Publicado: (2023)

Immunotherapy of acute myeloid leukemia based on γδ T cells
por: Gertner-Dardenne, Julie, et al.
Publicado: (2012)

Azacitidine Plus Venetoclax for the Treatment of Relapsed and Newly Diagnosed Acute Myeloid Leukemia Patients
por: Garciaz, Sylvain, et al.
Publicado: (2022)

Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities
por: Le Roy, Aude, et al.
Publicado: (2018)

Downregulation of stromal syntenin sustains AML development
por: Leblanc, Raphael, et al.
Publicado: (2023)

NKp30 expression is a prognostic immune biomarker for stratification of patients with intermediate-risk acute myeloid leukemia
por: Chretien, Anne-Sophie, et al.
Publicado: (2017)

Correction: NKp30 expression is a prognostic immune biomarker for stratification of patients with intermediate-risk acute myeloid leukemia
por: Chretien, Anne-Sophie, et al.
Publicado: (2019)

Natural Killer Defective Maturation Is Associated with Adverse Clinical Outcome in Patients with Acute Myeloid Leukemia
por: Chretien, Anne-Sophie, et al.
Publicado: (2017)

Real-life Use of Bexarotene for T-cell Cutaneous Lymphoma Management: Efficacy and Tolerance with Low Doses
por: ROUANET, Jacques, et al.
Publicado: (2022)

Memory-Efficient Training for Fully Unrolled Deep Learned PET Image Reconstruction with Iteration-Dependent Targets
por: Corda-D’Incan, Guillaume, et al.
Publicado: (2022)

BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation
por: Gertner-Dardenne, Julie, et al.
Publicado: (2013)

PB1810: OUTCOME OF ACUTE MYELOID LEUKEMIA RELAPSE AFTER ALLOGENIC STEM CELL TRANSPLANT: A SINGLE INSTITUTION RETROSPECTIVE STUDY
por: Castoldi, C., et al.
Publicado: (2022)

A phase 1 study of lirilumab (antibody against killer immunoglobulin-like receptor antibody KIR2D; IPH2102) in patients with solid tumors and hematologic malignancies
por: Vey, Norbert, et al.
Publicado: (2018)

Prognostic Immune Effector Signature in Adult Acute Lymphoblastic Leukemia Patients Is Dominated by γδ T Cells
por: Le Floch, Anne-Charlotte, et al.
Publicado: (2023)

Saprochaete clavata Outbreak Infecting Cancer Center through Dishwasher
por: Menu, Estelle, et al.
Publicado: (2020)

Biomarkers as targets for CAR-T/NK cell therapy in AML
por: Shao, Ruonan, et al.
Publicado: (2023)

Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses
por: JALENQUES, Isabelle, et al.
Publicado: (2020)

Long-term disease-free survival in advanced melanomas treated with nitrosoureas: mechanisms and new perspectives
por: Durando, Xavier, et al.
Publicado: (2005)

Phase I Trial of Prophylactic Donor-Derived IL-2-Activated NK Cell Infusion after Allogeneic Hematopoietic Stem Cell Transplantation from a Matched Sibling Donor
por: Devillier, Raynier, et al.
Publicado: (2021)

NK Cell Reconstitution After Autologous Hematopoietic Stem Cell Transplantation: Association Between NK Cell Maturation Stage and Outcome in Multiple Myeloma
por: Orrantia, Ane, et al.
Publicado: (2021)

Absence de relation directe entre l’épidémie récente d’engelures et l’infection par le SARS-CoV-2 : étude virologique de 10 cas consécutifs
por: Rouanet, J., et al.
Publicado: (2020)

Prevalence and Odds of Anxiety Disorders and Anxiety Symptoms in Children and Adults with Psoriasis: Systematic Review and Meta-analysis
por: JALENQUES, Isabelle, et al.
Publicado: (2022)

Psychiatric symptomatology in skin-restricted lupus patients without axis I psychiatric disorders: A post-hoc analysis
por: Rondepierre, Fabien, et al.
Publicado: (2023)

Repression of GSK3 restores NK cell cytotoxicity in AML patients
por: Parameswaran, Reshmi, et al.
Publicado: (2016)

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients
por: Rakova, Jana, et al.
Publicado: (2021)

A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study
por: Collignon, A., et al.
Publicado: (2020)

Azacitidine-induced reconstitution of the bone marrow T cell repertoire is associated with superior survival in AML patients
por: Grimm, Juliane, et al.
Publicado: (2022)

Influence of KIR and NK Cell Reconstitution in the Outcomes of Hematopoietic Stem Cell Transplantation
por: Gao, Fei, et al.
Publicado: (2020)

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
por: Björkström, Niklas K., et al.
Publicado: (2011)

Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation
por: Park, Ki Hyun, et al.
Publicado: (2020)

NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML
por: Schlegel, Patrick, et al.
Publicado: (2015)

RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations
por: Sidorova, Olga Alexandra, et al.
Publicado: (2022)

Donor selection for adoptive immunotherapy with NK cells in AML patients: Comparison between analysis of lytic NK cell clones and phenotypical identification of alloreactive NK cell repertoire
por: Meazza, Raffaella, et al.
Publicado: (2023)

Tuberculosis but not Immune Reconstitution Inflammatory Syndrome (IRIS) prevents early and late NK cell degranulation reconstitution in HIV/TB co-infected patients
por: Pean, Polidy, et al.
Publicado: (2011)

Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
por: Palau, Anna, et al.
Publicado: (2023)

P1426: WU-NK-101, AN ALLOGENEIC MEMORY NK CELL, FOR THE TREATMENT OF RELAPSE OR REFRACTORY (R/R) ACUTE MYELOID LEUKEMIA (AML)
por: Muth, J. J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g0nratp8pvk0b281v0elcuic40