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The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats

Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Pun...

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Autores principales: Nasiri, Ebrahim, Hosseinimehr, Seyed Jalal, Akbari, Jafar, Azadbakht, Mohammad, Azizi, Soheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288512/
https://www.ncbi.nlm.nih.gov/pubmed/28203250
http://dx.doi.org/10.1155/2017/3059745
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author Nasiri, Ebrahim
Hosseinimehr, Seyed Jalal
Akbari, Jafar
Azadbakht, Mohammad
Azizi, Soheil
author_facet Nasiri, Ebrahim
Hosseinimehr, Seyed Jalal
Akbari, Jafar
Azadbakht, Mohammad
Azizi, Soheil
author_sort Nasiri, Ebrahim
collection PubMed
description Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content in P. granatum extract was determined. Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum extract than in rats treated with cream containing SSD (2.8 ± 0.9 cm(2) versus 8.4 ± 3.2 cm(2)). The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. Conclusion. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries.
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spelling pubmed-52885122017-02-15 The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats Nasiri, Ebrahim Hosseinimehr, Seyed Jalal Akbari, Jafar Azadbakht, Mohammad Azizi, Soheil Adv Pharmacol Sci Research Article Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content in P. granatum extract was determined. Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum extract than in rats treated with cream containing SSD (2.8 ± 0.9 cm(2) versus 8.4 ± 3.2 cm(2)). The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. Conclusion. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries. Hindawi Publishing Corporation 2017 2017-01-19 /pmc/articles/PMC5288512/ /pubmed/28203250 http://dx.doi.org/10.1155/2017/3059745 Text en Copyright © 2017 Ebrahim Nasiri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nasiri, Ebrahim
Hosseinimehr, Seyed Jalal
Akbari, Jafar
Azadbakht, Mohammad
Azizi, Soheil
The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats
title The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats
title_full The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats
title_fullStr The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats
title_full_unstemmed The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats
title_short The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats
title_sort effects of punica granatum flower extract on skin injuries induced by burn in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288512/
https://www.ncbi.nlm.nih.gov/pubmed/28203250
http://dx.doi.org/10.1155/2017/3059745
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