Granzyme B; the chalk-mark of a cytotoxic lymphocyte

During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be...

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Detalles Bibliográficos
Autores principales: Waterhouse, Nigel J, Sedelies, Karin A, Clarke, Chris JP
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528853/
https://www.ncbi.nlm.nih.gov/pubmed/15500699
http://dx.doi.org/10.1186/1479-5876-2-36
Descripción
Sumario:During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells.

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