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Human Intestinal Barrier Function in Health and Disease

The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmles...

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Autores principales: König, Julia, Wells, Jerry, Cani, Patrice D, García-Ródenas, Clara L, MacDonald, Tom, Mercenier, Annick, Whyte, Jacqueline, Troost, Freddy, Brummer, Robert-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288588/
https://www.ncbi.nlm.nih.gov/pubmed/27763627
http://dx.doi.org/10.1038/ctg.2016.54
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author König, Julia
Wells, Jerry
Cani, Patrice D
García-Ródenas, Clara L
MacDonald, Tom
Mercenier, Annick
Whyte, Jacqueline
Troost, Freddy
Brummer, Robert-Jan
author_facet König, Julia
Wells, Jerry
Cani, Patrice D
García-Ródenas, Clara L
MacDonald, Tom
Mercenier, Annick
Whyte, Jacqueline
Troost, Freddy
Brummer, Robert-Jan
author_sort König, Julia
collection PubMed
description The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed. In addition, the effect of the frequently prescribed drugs proton pump inhibitors and non-steroidal anti-inflammatory drugs on intestinal permeability, as well as commonly used methods to assess barrier function will be reviewed.
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spelling pubmed-52885882017-02-07 Human Intestinal Barrier Function in Health and Disease König, Julia Wells, Jerry Cani, Patrice D García-Ródenas, Clara L MacDonald, Tom Mercenier, Annick Whyte, Jacqueline Troost, Freddy Brummer, Robert-Jan Clin Transl Gastroenterol Clinical Review The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed. In addition, the effect of the frequently prescribed drugs proton pump inhibitors and non-steroidal anti-inflammatory drugs on intestinal permeability, as well as commonly used methods to assess barrier function will be reviewed. Nature Publishing Group 2016-10 2016-10-20 /pmc/articles/PMC5288588/ /pubmed/27763627 http://dx.doi.org/10.1038/ctg.2016.54 Text en Copyright © 2016 The Author(s) the American College of Gastroenterology http://creativecommons.org/licenses/by-nc-nd/4.0/ Clinical and Translational Gastroenterology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Clinical Review
König, Julia
Wells, Jerry
Cani, Patrice D
García-Ródenas, Clara L
MacDonald, Tom
Mercenier, Annick
Whyte, Jacqueline
Troost, Freddy
Brummer, Robert-Jan
Human Intestinal Barrier Function in Health and Disease
title Human Intestinal Barrier Function in Health and Disease
title_full Human Intestinal Barrier Function in Health and Disease
title_fullStr Human Intestinal Barrier Function in Health and Disease
title_full_unstemmed Human Intestinal Barrier Function in Health and Disease
title_short Human Intestinal Barrier Function in Health and Disease
title_sort human intestinal barrier function in health and disease
topic Clinical Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288588/
https://www.ncbi.nlm.nih.gov/pubmed/27763627
http://dx.doi.org/10.1038/ctg.2016.54
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