Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation

Chronic low dose inorganic arsenic (iAs) exposure leads to changes in gene expression and epithelial-to-mesenchymal transformation. During this transformation, cells adopt a fibroblast-like phenotype accompanied by profound gene expression changes. While many mechanisms have been implicated in this...

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Detalles Bibliográficos
Autores principales: Rea, Matthew, Eckstein, Meredith, Eleazer, Rebekah, Smith, Caroline, Fondufe-Mittendorf , Yvonne N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288714/
https://www.ncbi.nlm.nih.gov/pubmed/28150704
http://dx.doi.org/10.1038/srep41474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288714/
https://www.ncbi.nlm.nih.gov/pubmed/28150704
http://dx.doi.org/10.1038/srep41474

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