The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases

Human pathogenic positive single strand RNA ((+)ssRNA) viruses, including Chikungunya virus, pose severe health problems as for many neither efficient vaccines nor therapeutic strategies exist. To interfere with propagation, viral enzymatic activities are considered potential targets. Here we addres...

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Detalles Bibliográficos
Autores principales: Eckei, Laura, Krieg, Sarah, Bütepage, Mareike, Lehmann, Anne, Gross, Annika, Lippok, Barbara, Grimm, Alexander R., Kümmerer, Beate M., Rossetti, Giulia, Lüscher, Bernhard, Verheugd, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288732/
https://www.ncbi.nlm.nih.gov/pubmed/28150709
http://dx.doi.org/10.1038/srep41746

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