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Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo

Mesoporous silica‐based nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages, except for their complex purification procedures and structures that are difficult to decompose. In this work, biocompatible hyperbranched polyglycerol is introduced to syn...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Wang, Anhe, Wei, Qiang, Schlesener, Cathleen, Haag, Rainer, Li, Qi, Li, Junbai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288762/
https://www.ncbi.nlm.nih.gov/pubmed/28168161
http://dx.doi.org/10.1002/open.201600072
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author Yang, Yang
Wang, Anhe
Wei, Qiang
Schlesener, Cathleen
Haag, Rainer
Li, Qi
Li, Junbai
author_facet Yang, Yang
Wang, Anhe
Wei, Qiang
Schlesener, Cathleen
Haag, Rainer
Li, Qi
Li, Junbai
author_sort Yang, Yang
collection PubMed
description Mesoporous silica‐based nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages, except for their complex purification procedures and structures that are difficult to decompose. In this work, biocompatible hyperbranched polyglycerol is introduced to synthesize mesoporous silica nanoparticles (MSNs). The materials possess good biocompatibility, controlled release, and biodegradability. They also show passive targeting capability through the enhanced permeability and retention effect and can be excreted from the biological system. The method avoids the needs to employ traditional surfactants and complicated purified procedures, which make these MSNs an efficient delivery system for cancer therapy.
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spelling pubmed-52887622017-02-06 Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo Yang, Yang Wang, Anhe Wei, Qiang Schlesener, Cathleen Haag, Rainer Li, Qi Li, Junbai ChemistryOpen Full Papers Mesoporous silica‐based nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages, except for their complex purification procedures and structures that are difficult to decompose. In this work, biocompatible hyperbranched polyglycerol is introduced to synthesize mesoporous silica nanoparticles (MSNs). The materials possess good biocompatibility, controlled release, and biodegradability. They also show passive targeting capability through the enhanced permeability and retention effect and can be excreted from the biological system. The method avoids the needs to employ traditional surfactants and complicated purified procedures, which make these MSNs an efficient delivery system for cancer therapy. John Wiley and Sons Inc. 2016-12-12 /pmc/articles/PMC5288762/ /pubmed/28168161 http://dx.doi.org/10.1002/open.201600072 Text en © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Yang, Yang
Wang, Anhe
Wei, Qiang
Schlesener, Cathleen
Haag, Rainer
Li, Qi
Li, Junbai
Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
title Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
title_full Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
title_fullStr Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
title_full_unstemmed Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
title_short Hyperbranched Polyglycerol‐Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo
title_sort hyperbranched polyglycerol‐induced porous silica nanoparticles as drug carriers for cancer therapy in vitro and in vivo
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288762/
https://www.ncbi.nlm.nih.gov/pubmed/28168161
http://dx.doi.org/10.1002/open.201600072
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