P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus

Mice deficient in P-Selectin presented altered immunity/tolerance balance. We have observed that the absence of P-Selectin promotes splenomegaly with reduced naïve T cell population, elevated activated/effector T cell subset, increased germinal center B and Tfh populations and high production of aut...

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Detalles Bibliográficos
Autores principales: González-Tajuelo, Rafael, Silván, Javier, Pérez-Frías, Alicia, de la Fuente-Fernández, María, Tejedor, Reyes, Espartero-Santos, Marina, Vicente-Rabaneda, Esther, Juarranz, Ángeles, Muñoz-Calleja, Cecilia, Castañeda, Santos, Gamallo, Carlos, Urzainqui, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288776/
https://www.ncbi.nlm.nih.gov/pubmed/28150814
http://dx.doi.org/10.1038/srep41841

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