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Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure. Mutation of the ABCB11 gene encoding BSEP induces BSEP deficiency and progressive familial intrahepatic cholestasis type 2 (PFIC2). Because live...

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Detalles Bibliográficos
Autores principales:	Imagawa, Kazuo, Takayama, Kazuo, Isoyama, Shigemi, Tanikawa, Ken, Shinkai, Masato, Harada, Kazuo, Tachibana, Masashi, Sakurai, Fuminori, Noguchi, Emiko, Hirata, Kazumasa, Kage, Masayoshi, Kawabata, Kenji, Sumazaki, Ryo, Mizuguchi, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288783/ https://www.ncbi.nlm.nih.gov/pubmed/28150711 http://dx.doi.org/10.1038/srep41806

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