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Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder

BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patie...

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Autores principales: Zhu, Yikang, Tang, Yunxiang, Zhang, Tianhong, Li, Hui, Tang, Yingying, Li, Chunbo, Luo, Xingguang, He, Yongguang, Lu, Zheng, Wang, Jijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288938/
https://www.ncbi.nlm.nih.gov/pubmed/28152990
http://dx.doi.org/10.1186/s12888-016-1146-5
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author Zhu, Yikang
Tang, Yunxiang
Zhang, Tianhong
Li, Hui
Tang, Yingying
Li, Chunbo
Luo, Xingguang
He, Yongguang
Lu, Zheng
Wang, Jijun
author_facet Zhu, Yikang
Tang, Yunxiang
Zhang, Tianhong
Li, Hui
Tang, Yingying
Li, Chunbo
Luo, Xingguang
He, Yongguang
Lu, Zheng
Wang, Jijun
author_sort Zhu, Yikang
collection PubMed
description BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. METHODS: Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. RESULTS: Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left parahippocampus (r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right parahippocampus (r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left parahippocampus (r = −0.535, p = 0.018) in SPD group. CONCLUSIONS: Our findings suggest that the decreased functional connectivity between precuneus and contralateral parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder.
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spelling pubmed-52889382017-02-09 Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder Zhu, Yikang Tang, Yunxiang Zhang, Tianhong Li, Hui Tang, Yingying Li, Chunbo Luo, Xingguang He, Yongguang Lu, Zheng Wang, Jijun BMC Psychiatry Research Article BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. METHODS: Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. RESULTS: Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left parahippocampus (r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right parahippocampus (r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left parahippocampus (r = −0.535, p = 0.018) in SPD group. CONCLUSIONS: Our findings suggest that the decreased functional connectivity between precuneus and contralateral parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder. BioMed Central 2017-02-02 /pmc/articles/PMC5288938/ /pubmed/28152990 http://dx.doi.org/10.1186/s12888-016-1146-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhu, Yikang
Tang, Yunxiang
Zhang, Tianhong
Li, Hui
Tang, Yingying
Li, Chunbo
Luo, Xingguang
He, Yongguang
Lu, Zheng
Wang, Jijun
Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
title Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
title_full Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
title_fullStr Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
title_full_unstemmed Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
title_short Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
title_sort reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288938/
https://www.ncbi.nlm.nih.gov/pubmed/28152990
http://dx.doi.org/10.1186/s12888-016-1146-5
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