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Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patie...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288938/ https://www.ncbi.nlm.nih.gov/pubmed/28152990 http://dx.doi.org/10.1186/s12888-016-1146-5 |
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author | Zhu, Yikang Tang, Yunxiang Zhang, Tianhong Li, Hui Tang, Yingying Li, Chunbo Luo, Xingguang He, Yongguang Lu, Zheng Wang, Jijun |
author_facet | Zhu, Yikang Tang, Yunxiang Zhang, Tianhong Li, Hui Tang, Yingying Li, Chunbo Luo, Xingguang He, Yongguang Lu, Zheng Wang, Jijun |
author_sort | Zhu, Yikang |
collection | PubMed |
description | BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. METHODS: Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. RESULTS: Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left parahippocampus (r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right parahippocampus (r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left parahippocampus (r = −0.535, p = 0.018) in SPD group. CONCLUSIONS: Our findings suggest that the decreased functional connectivity between precuneus and contralateral parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder. |
format | Online Article Text |
id | pubmed-5288938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52889382017-02-09 Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder Zhu, Yikang Tang, Yunxiang Zhang, Tianhong Li, Hui Tang, Yingying Li, Chunbo Luo, Xingguang He, Yongguang Lu, Zheng Wang, Jijun BMC Psychiatry Research Article BACKGROUND: Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD. METHODS: Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method. RESULTS: Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left parahippocampus (r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right parahippocampus (r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left parahippocampus (r = −0.535, p = 0.018) in SPD group. CONCLUSIONS: Our findings suggest that the decreased functional connectivity between precuneus and contralateral parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder. BioMed Central 2017-02-02 /pmc/articles/PMC5288938/ /pubmed/28152990 http://dx.doi.org/10.1186/s12888-016-1146-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhu, Yikang Tang, Yunxiang Zhang, Tianhong Li, Hui Tang, Yingying Li, Chunbo Luo, Xingguang He, Yongguang Lu, Zheng Wang, Jijun Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
title | Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
title_full | Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
title_fullStr | Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
title_full_unstemmed | Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
title_short | Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
title_sort | reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288938/ https://www.ncbi.nlm.nih.gov/pubmed/28152990 http://dx.doi.org/10.1186/s12888-016-1146-5 |
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