The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity

Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) f...

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Autores principales: Vatrinet, Renaud, Leone, Giulia, De Luise, Monica, Girolimetti, Giulia, Vidone, Michele, Gasparre, Giuseppe, Porcelli, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289018/
https://www.ncbi.nlm.nih.gov/pubmed/28184304
http://dx.doi.org/10.1186/s40170-017-0165-0
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author Vatrinet, Renaud
Leone, Giulia
De Luise, Monica
Girolimetti, Giulia
Vidone, Michele
Gasparre, Giuseppe
Porcelli, Anna Maria
author_facet Vatrinet, Renaud
Leone, Giulia
De Luise, Monica
Girolimetti, Giulia
Vidone, Michele
Gasparre, Giuseppe
Porcelli, Anna Maria
author_sort Vatrinet, Renaud
collection PubMed
description Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell’s change in bioenergetic requirements. By contributing to the control of α-ketoglutarate levels, dynamics, and oxidation state, the α-ketoglutarate dehydrogenase is also essential in modulating the epigenetic landscape of cancer cells. In this review, we will discuss the manifold roles that this TCA enzyme and its substrate play in cancer.
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spelling pubmed-52890182017-02-09 The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity Vatrinet, Renaud Leone, Giulia De Luise, Monica Girolimetti, Giulia Vidone, Michele Gasparre, Giuseppe Porcelli, Anna Maria Cancer Metab Review Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell’s change in bioenergetic requirements. By contributing to the control of α-ketoglutarate levels, dynamics, and oxidation state, the α-ketoglutarate dehydrogenase is also essential in modulating the epigenetic landscape of cancer cells. In this review, we will discuss the manifold roles that this TCA enzyme and its substrate play in cancer. BioMed Central 2017-02-02 /pmc/articles/PMC5289018/ /pubmed/28184304 http://dx.doi.org/10.1186/s40170-017-0165-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Vatrinet, Renaud
Leone, Giulia
De Luise, Monica
Girolimetti, Giulia
Vidone, Michele
Gasparre, Giuseppe
Porcelli, Anna Maria
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
title The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
title_full The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
title_fullStr The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
title_full_unstemmed The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
title_short The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
title_sort α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289018/
https://www.ncbi.nlm.nih.gov/pubmed/28184304
http://dx.doi.org/10.1186/s40170-017-0165-0
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