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Relationship between lead exposure and mild cognitive impairment

INTRODUCTION. Since it is still controversial whether-low-to moderate long-term lead below current threshold values causes neurobehavioural deficits in adults. METHODS. Forty lead-exposed workers subjects with a mean blood lead (PbB) level of 56.4 μg/dL and 40 non-lead-exposed aged matched subjects...

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Autores principales: FENGA, C., GANGEMI, S., ALIBRANDI, A., COSTA, C., MICALI, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore SRL 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289032/
https://www.ncbi.nlm.nih.gov/pubmed/28167858
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author FENGA, C.
GANGEMI, S.
ALIBRANDI, A.
COSTA, C.
MICALI, E.
author_facet FENGA, C.
GANGEMI, S.
ALIBRANDI, A.
COSTA, C.
MICALI, E.
author_sort FENGA, C.
collection PubMed
description INTRODUCTION. Since it is still controversial whether-low-to moderate long-term lead below current threshold values causes neurobehavioural deficits in adults. METHODS. Forty lead-exposed workers subjects with a mean blood lead (PbB) level of 56.4 μg/dL and 40 non-lead-exposed aged matched subjects (PbB: 15.4 μg/dL) with the same socio-economic background were investigated. Participants were administered a neuropsychological tests consisting of BAMT (Branches Alternate Movements Task), FT (Finger Tapping Speed), DS (Digit Span) POMS (Profile of Mood States). RESULTS. Authors noted a significant relationship between the exposed and the referent groups in tests mainly involving executive functions, short time memory and psycho-emotional variables. In addition, Poisson regression test performed on single psychoemotional factors (POMS), has allowed to evidence a significant influence of Pb e ZPP levels on tension, anxiety and depression. CONCLUSIONS. The present study showed that lead exposure among adults at levels previously considered safe, results in impairment of certain cognitive abilities.
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spelling pubmed-52890322017-02-06 Relationship between lead exposure and mild cognitive impairment FENGA, C. GANGEMI, S. ALIBRANDI, A. COSTA, C. MICALI, E. J Prev Med Hyg Original Article INTRODUCTION. Since it is still controversial whether-low-to moderate long-term lead below current threshold values causes neurobehavioural deficits in adults. METHODS. Forty lead-exposed workers subjects with a mean blood lead (PbB) level of 56.4 μg/dL and 40 non-lead-exposed aged matched subjects (PbB: 15.4 μg/dL) with the same socio-economic background were investigated. Participants were administered a neuropsychological tests consisting of BAMT (Branches Alternate Movements Task), FT (Finger Tapping Speed), DS (Digit Span) POMS (Profile of Mood States). RESULTS. Authors noted a significant relationship between the exposed and the referent groups in tests mainly involving executive functions, short time memory and psycho-emotional variables. In addition, Poisson regression test performed on single psychoemotional factors (POMS), has allowed to evidence a significant influence of Pb e ZPP levels on tension, anxiety and depression. CONCLUSIONS. The present study showed that lead exposure among adults at levels previously considered safe, results in impairment of certain cognitive abilities. Pacini Editore SRL 2016-12 /pmc/articles/PMC5289032/ /pubmed/28167858 Text en © Copyright by Pacini Editore SRL, Pisa, Italy http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
FENGA, C.
GANGEMI, S.
ALIBRANDI, A.
COSTA, C.
MICALI, E.
Relationship between lead exposure and mild cognitive impairment
title Relationship between lead exposure and mild cognitive impairment
title_full Relationship between lead exposure and mild cognitive impairment
title_fullStr Relationship between lead exposure and mild cognitive impairment
title_full_unstemmed Relationship between lead exposure and mild cognitive impairment
title_short Relationship between lead exposure and mild cognitive impairment
title_sort relationship between lead exposure and mild cognitive impairment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289032/
https://www.ncbi.nlm.nih.gov/pubmed/28167858
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