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Composite Lymphoma: Opposite Ends of Spectrum Meet

An 18-year-old African-American female presented with an episode of syncope. Initial investigations revealed large lung mass with invasion into right atrium along with lesions in kidneys and liver. Patient also developed superior vena cava syndrome due to lung mass. Biopsy of lung mass revealed diag...

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Autores principales: Khan, Uqba, Hadid, Tarik, Ibrar, Warda, Sano, Dahlia, Al-Katib, Ayad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289141/
https://www.ncbi.nlm.nih.gov/pubmed/28179969
http://dx.doi.org/10.14740/jocmr2929w
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author Khan, Uqba
Hadid, Tarik
Ibrar, Warda
Sano, Dahlia
Al-Katib, Ayad
author_facet Khan, Uqba
Hadid, Tarik
Ibrar, Warda
Sano, Dahlia
Al-Katib, Ayad
author_sort Khan, Uqba
collection PubMed
description An 18-year-old African-American female presented with an episode of syncope. Initial investigations revealed large lung mass with invasion into right atrium along with lesions in kidneys and liver. Patient also developed superior vena cava syndrome due to lung mass. Biopsy of lung mass revealed diagnosis of composite lymphoma with involvement by primary mediastinal B-cell lymphoma (PMBCL) and classical Hodgkin lymphoma. Patient was started on dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (EPOCH-R) with complete response to treatment. This case represents an extremely rare type of aggressive lymphoma and can guide clinicians in managing such cases since there are no standard guidelines for treatment. To the best of our knowledge, this is the first reported case of composite lymphoma of PMBCL and classical Hodgkin lymphoma successfully treated with dose-adjusted EPOCH-R regimen.
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spelling pubmed-52891412017-02-08 Composite Lymphoma: Opposite Ends of Spectrum Meet Khan, Uqba Hadid, Tarik Ibrar, Warda Sano, Dahlia Al-Katib, Ayad J Clin Med Res Case Report An 18-year-old African-American female presented with an episode of syncope. Initial investigations revealed large lung mass with invasion into right atrium along with lesions in kidneys and liver. Patient also developed superior vena cava syndrome due to lung mass. Biopsy of lung mass revealed diagnosis of composite lymphoma with involvement by primary mediastinal B-cell lymphoma (PMBCL) and classical Hodgkin lymphoma. Patient was started on dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (EPOCH-R) with complete response to treatment. This case represents an extremely rare type of aggressive lymphoma and can guide clinicians in managing such cases since there are no standard guidelines for treatment. To the best of our knowledge, this is the first reported case of composite lymphoma of PMBCL and classical Hodgkin lymphoma successfully treated with dose-adjusted EPOCH-R regimen. Elmer Press 2017-03 2017-01-25 /pmc/articles/PMC5289141/ /pubmed/28179969 http://dx.doi.org/10.14740/jocmr2929w Text en Copyright 2017, Khan et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Khan, Uqba
Hadid, Tarik
Ibrar, Warda
Sano, Dahlia
Al-Katib, Ayad
Composite Lymphoma: Opposite Ends of Spectrum Meet
title Composite Lymphoma: Opposite Ends of Spectrum Meet
title_full Composite Lymphoma: Opposite Ends of Spectrum Meet
title_fullStr Composite Lymphoma: Opposite Ends of Spectrum Meet
title_full_unstemmed Composite Lymphoma: Opposite Ends of Spectrum Meet
title_short Composite Lymphoma: Opposite Ends of Spectrum Meet
title_sort composite lymphoma: opposite ends of spectrum meet
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289141/
https://www.ncbi.nlm.nih.gov/pubmed/28179969
http://dx.doi.org/10.14740/jocmr2929w
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