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Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)

Two radiated tortoises (Astrochelys radiata) exhibited anorexia and hypokinesia. In both cases, hematological and serum biochemical examinations revealed high alkaline phosphatase levels, moderately high aspartate aminotransferase levels and white blood cell counts approximately within the normal ra...

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Autores principales: KIDO, Nobuhide, ITAGAKI, Iori, KIRYU, Daisuke, OMIYA, Tomoko, ONO, Kaori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289255/
https://www.ncbi.nlm.nih.gov/pubmed/27746414
http://dx.doi.org/10.1292/jvms.16-0142
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author KIDO, Nobuhide
ITAGAKI, Iori
KIRYU, Daisuke
OMIYA, Tomoko
ONO, Kaori
author_facet KIDO, Nobuhide
ITAGAKI, Iori
KIRYU, Daisuke
OMIYA, Tomoko
ONO, Kaori
author_sort KIDO, Nobuhide
collection PubMed
description Two radiated tortoises (Astrochelys radiata) exhibited anorexia and hypokinesia. In both cases, hematological and serum biochemical examinations revealed high alkaline phosphatase levels, moderately high aspartate aminotransferase levels and white blood cell counts approximately within the normal range. Despite being treated, the tortoises died 9 and 43 days after the first clinical examination. Gross pathological examinations revealed that the livers of both animals were extremely swollen and contained pale yellow necrotic tissue. Histopathological assessment revealed that the livers contained a massive area of hepatic necrosis surrounded by migration of macrophages and multinucleated giant cells. In one of the cases, severe fibrosis was observed. The present study provides reference information for similar cases in the future.
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spelling pubmed-52892552017-02-08 Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata) KIDO, Nobuhide ITAGAKI, Iori KIRYU, Daisuke OMIYA, Tomoko ONO, Kaori J Vet Med Sci Wildlife Science Two radiated tortoises (Astrochelys radiata) exhibited anorexia and hypokinesia. In both cases, hematological and serum biochemical examinations revealed high alkaline phosphatase levels, moderately high aspartate aminotransferase levels and white blood cell counts approximately within the normal range. Despite being treated, the tortoises died 9 and 43 days after the first clinical examination. Gross pathological examinations revealed that the livers of both animals were extremely swollen and contained pale yellow necrotic tissue. Histopathological assessment revealed that the livers contained a massive area of hepatic necrosis surrounded by migration of macrophages and multinucleated giant cells. In one of the cases, severe fibrosis was observed. The present study provides reference information for similar cases in the future. The Japanese Society of Veterinary Science 2016-10-16 2017-01 /pmc/articles/PMC5289255/ /pubmed/27746414 http://dx.doi.org/10.1292/jvms.16-0142 Text en ©2017 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Wildlife Science
KIDO, Nobuhide
ITAGAKI, Iori
KIRYU, Daisuke
OMIYA, Tomoko
ONO, Kaori
Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)
title Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)
title_full Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)
title_fullStr Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)
title_full_unstemmed Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)
title_short Hematological and pathological features of massive hepatic necrosis in two radiated tortoises (Astrochelys radiata)
title_sort hematological and pathological features of massive hepatic necrosis in two radiated tortoises (astrochelys radiata)
topic Wildlife Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289255/
https://www.ncbi.nlm.nih.gov/pubmed/27746414
http://dx.doi.org/10.1292/jvms.16-0142
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