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High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. OBJECTIVE: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesio...

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Detalles Bibliográficos
Autores principales: RIBEIRO, Mariana Goveia Melo, MARCOLINO, Larissa Doddi, RAMOS, Bruna Ribeiro de Andrade, MIRANDA, Elaine Alves, TRENTO, Cleverson Luciano, JAIN, Sona, GURGEL, Ricardo Queiroz, da SILVA, Márcia Guimarães, DOLABELLA, Silvio Santana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade De Odontologia De Bauru - USP 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289402/
https://www.ncbi.nlm.nih.gov/pubmed/28198978
http://dx.doi.org/10.1590/1678-77572016-0313
Descripción
Sumario:The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. OBJECTIVE: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. MATERIAL AND METHODS: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. RESULTS: Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). CONCLUSION: Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions.