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Cannabinoid antagonist SLV326 induces convulsive seizures and changes in the interictal EEG in rats
Cannabinoid CB1 antagonists have been investigated for possible treatment of e.g. obesity-related disorders. However, clinical application was halted due to their symptoms of anxiety and depression. In addition to these adverse effects, we have shown earlier that chronic treatment with the CB1 antag...
Autores principales: | Perescis, Martin F. J., de Bruin, Natasja, Heijink, Liesbeth, Kruse, Chris, Vinogradova, Lyudmila, Lüttjohann, Annika, van Luijtelaar, Gilles, van Rijn, Clementina M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289424/ https://www.ncbi.nlm.nih.gov/pubmed/28151935 http://dx.doi.org/10.1371/journal.pone.0165363 |
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