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Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012

Although serogroup 6 was among the first to be recognized among Streptococcus pneumoniae, several new serotypes were identified since the introduction of pneumococcal conjugate vaccines (PCVs). A decrease of the 6B-2 variant among invasive pneumococcal disease (IPD), but not 6B-1, was noted post con...

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Autores principales: Diamantino-Miranda, Jorge, Aguiar, Sandra Isabel, Carriço, João André, Melo-Cristino, José, Ramirez, Mário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289433/
https://www.ncbi.nlm.nih.gov/pubmed/28152029
http://dx.doi.org/10.1371/journal.pone.0170354
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author Diamantino-Miranda, Jorge
Aguiar, Sandra Isabel
Carriço, João André
Melo-Cristino, José
Ramirez, Mário
author_facet Diamantino-Miranda, Jorge
Aguiar, Sandra Isabel
Carriço, João André
Melo-Cristino, José
Ramirez, Mário
author_sort Diamantino-Miranda, Jorge
collection PubMed
description Although serogroup 6 was among the first to be recognized among Streptococcus pneumoniae, several new serotypes were identified since the introduction of pneumococcal conjugate vaccines (PCVs). A decrease of the 6B-2 variant among invasive pneumococcal disease (IPD), but not 6B-1, was noted post conjugate vaccine introduction, underpinned by a decrease of CC273 isolates. Serotype 6C was associated with adult IPD and increased in this age group representing two lineages (CC315 and CC395), while the same lineages expressed other serogroup 6 serotypes in children. Taken together, these findings suggest a potential cross-protection of PCVs against serotype 6C IPD among vaccinated children but not among adults. Serotype 6A became the most important serogroup 6 serotype in children but it decreased in adult IPD. No other serogroup 6 serotypes were detected, so available phenotypic or simple genotypic assays remain adequate for distinguishing serotypes within serogroup 6 isolates.
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spelling pubmed-52894332017-02-17 Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012 Diamantino-Miranda, Jorge Aguiar, Sandra Isabel Carriço, João André Melo-Cristino, José Ramirez, Mário PLoS One Research Article Although serogroup 6 was among the first to be recognized among Streptococcus pneumoniae, several new serotypes were identified since the introduction of pneumococcal conjugate vaccines (PCVs). A decrease of the 6B-2 variant among invasive pneumococcal disease (IPD), but not 6B-1, was noted post conjugate vaccine introduction, underpinned by a decrease of CC273 isolates. Serotype 6C was associated with adult IPD and increased in this age group representing two lineages (CC315 and CC395), while the same lineages expressed other serogroup 6 serotypes in children. Taken together, these findings suggest a potential cross-protection of PCVs against serotype 6C IPD among vaccinated children but not among adults. Serotype 6A became the most important serogroup 6 serotype in children but it decreased in adult IPD. No other serogroup 6 serotypes were detected, so available phenotypic or simple genotypic assays remain adequate for distinguishing serotypes within serogroup 6 isolates. Public Library of Science 2017-02-02 /pmc/articles/PMC5289433/ /pubmed/28152029 http://dx.doi.org/10.1371/journal.pone.0170354 Text en © 2017 Diamantino-Miranda et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Diamantino-Miranda, Jorge
Aguiar, Sandra Isabel
Carriço, João André
Melo-Cristino, José
Ramirez, Mário
Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012
title Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012
title_full Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012
title_fullStr Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012
title_full_unstemmed Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012
title_short Clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in Portugal: 1999-2012
title_sort clonal and serotype dynamics of serogroup 6 isolates causing invasive pneumococcal disease in portugal: 1999-2012
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289433/
https://www.ncbi.nlm.nih.gov/pubmed/28152029
http://dx.doi.org/10.1371/journal.pone.0170354
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