Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility

Kawasaki disease (KD) is the most common acquired pediatric heart disease. We analyzed Whole Genome Sequences (WGS) from a 6-member African American family in which KD affected two of four children. We sought rare, potentially causative genotypes by sequentially applying the following WGS filters: s...

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Detalles Bibliográficos
Autores principales: Kim, Jihoon, Shimizu, Chisato, Kingsmore, Stephen F., Veeraraghavan, Narayanan, Levy, Eric, Ribeiro dos Santos, Andre M., Yang, Hai, Flatley, Jay, Hoang, Long Truong, Hibberd, Martin L., Tremoulet, Adriana H., Harismendy, Olivier, Ohno-Machado, Lucila, Burns, Jane C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289527/
https://www.ncbi.nlm.nih.gov/pubmed/28151979
http://dx.doi.org/10.1371/journal.pone.0170977

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