NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease

Invariant NKT (iNKT) cells can be activated to stimulate a broad inflammatory response. In murine models of sickle cell disease (SCD), interruption of iNKT cell activity prevents tissue injury from vaso-occlusion. NKTT120 is an anti-iNKT cell monoclonal antibody that has the potential to rapidly and...

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Detalles Bibliográficos
Autores principales: Field, Joshua J., Majerus, Elaine, Ataga, Kenneth I., Vichinsky, Elliot P., Schaub, Robert, Mashal, Robert, Nathan, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289534/
https://www.ncbi.nlm.nih.gov/pubmed/28152086
http://dx.doi.org/10.1371/journal.pone.0171067

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