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A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets

The genetic component of complex disease risk in humans remains largely unexplained. A corollary is that the allelic spectrum of genetic variants contributing to complex disease risk is unknown. Theoretical models that relate population genetic processes to the maintenance of genetic variation for q...

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Detalles Bibliográficos
Autores principales:	Sanjak, Jaleal S., Long, Anthony D., Thornton, Kevin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289629/ https://www.ncbi.nlm.nih.gov/pubmed/28103232 http://dx.doi.org/10.1371/journal.pgen.1006573

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