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Identifying T Cell Receptors from High-Throughput Sequencing: Dealing with Promiscuity in TCRα and TCRβ Pairing

Characterisation of the T cell receptors (TCR) involved in immune responses is important for the design of vaccines and immunotherapies for cancer and autoimmune disease. The specificity of the interaction between the TCR heterodimer and its peptide-MHC ligand derives largely from the juxtaposed hyp...

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Detalles Bibliográficos
Autores principales:	Lee, Edward S., Thomas, Paul G., Mold, Jeff E., Yates, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289640/ https://www.ncbi.nlm.nih.gov/pubmed/28103239 http://dx.doi.org/10.1371/journal.pcbi.1005313

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