Adeno-Associated Virus Serotype 9–Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts With Left Ventricular Dysfunction Secondary to a Myocardial Infarction

Mutations in Bcl-2–associated athanogene 3 (BAG3) were associated with skeletal muscle dysfunction and dilated cardiomyopathy. Retro-orbital injection of an adeno-associated virus serotype 9 expressing BAG3 (rAAV9-BAG3) significantly (p < 0.0001) improved left ventricular ejection fraction, fract...

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Detalles Bibliográficos
Autores principales: Knezevic, Tijana, Myers, Valerie D., Su, Feifei, Wang, JuFang, Song, Jianliang, Zhang, Xue-Qian, Gao, Erhe, Gao, Guofeng, Madesh, Muniswamy, Gupta, Manish K., Gordon, Jennifer, Weiner, Kristen N., Rabinowitz, Joseph, Ramsey, Frederick V., Tilley, Douglas G., Khalili, Kamel, Cheung, Joseph Y., Feldman, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289821/
https://www.ncbi.nlm.nih.gov/pubmed/28164169
http://dx.doi.org/10.1016/j.jacbts.2016.08.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289821/
https://www.ncbi.nlm.nih.gov/pubmed/28164169
http://dx.doi.org/10.1016/j.jacbts.2016.08.008

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