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Modulation of Human Immune Response by Fungal Biocontrol Agents

Although the vast majority of biological control agents is generally regarded as safe for humans and environment, the increased exposure of agriculture workers, and consumer population to fungal substances may affect the immune system. Those compounds may be associated with both intense stimulation,...

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Detalles Bibliográficos
Autores principales: Konstantinovas, Cibele, de Oliveira Mendes, Tiago A., Vannier-Santos, Marcos A., Lima-Santos, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289975/
https://www.ncbi.nlm.nih.gov/pubmed/28217107
http://dx.doi.org/10.3389/fmicb.2017.00039
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author Konstantinovas, Cibele
de Oliveira Mendes, Tiago A.
Vannier-Santos, Marcos A.
Lima-Santos, Jane
author_facet Konstantinovas, Cibele
de Oliveira Mendes, Tiago A.
Vannier-Santos, Marcos A.
Lima-Santos, Jane
author_sort Konstantinovas, Cibele
collection PubMed
description Although the vast majority of biological control agents is generally regarded as safe for humans and environment, the increased exposure of agriculture workers, and consumer population to fungal substances may affect the immune system. Those compounds may be associated with both intense stimulation, resulting in IgE-mediated allergy and immune downmodulation induced by molecules such as cyclosporin A and mycotoxins. This review discusses the potential effects of biocontrol fungal components on human immune responses, possibly associated to infectious, inflammatory diseases, and defective defenses.
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spelling pubmed-52899752017-02-17 Modulation of Human Immune Response by Fungal Biocontrol Agents Konstantinovas, Cibele de Oliveira Mendes, Tiago A. Vannier-Santos, Marcos A. Lima-Santos, Jane Front Microbiol Microbiology Although the vast majority of biological control agents is generally regarded as safe for humans and environment, the increased exposure of agriculture workers, and consumer population to fungal substances may affect the immune system. Those compounds may be associated with both intense stimulation, resulting in IgE-mediated allergy and immune downmodulation induced by molecules such as cyclosporin A and mycotoxins. This review discusses the potential effects of biocontrol fungal components on human immune responses, possibly associated to infectious, inflammatory diseases, and defective defenses. Frontiers Media S.A. 2017-02-03 /pmc/articles/PMC5289975/ /pubmed/28217107 http://dx.doi.org/10.3389/fmicb.2017.00039 Text en Copyright © 2017 Konstantinovas, de Oliveira Mendes, Vannier-Santos and Lima-Santos. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Konstantinovas, Cibele
de Oliveira Mendes, Tiago A.
Vannier-Santos, Marcos A.
Lima-Santos, Jane
Modulation of Human Immune Response by Fungal Biocontrol Agents
title Modulation of Human Immune Response by Fungal Biocontrol Agents
title_full Modulation of Human Immune Response by Fungal Biocontrol Agents
title_fullStr Modulation of Human Immune Response by Fungal Biocontrol Agents
title_full_unstemmed Modulation of Human Immune Response by Fungal Biocontrol Agents
title_short Modulation of Human Immune Response by Fungal Biocontrol Agents
title_sort modulation of human immune response by fungal biocontrol agents
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289975/
https://www.ncbi.nlm.nih.gov/pubmed/28217107
http://dx.doi.org/10.3389/fmicb.2017.00039
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