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The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia

PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnanc...

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Autores principales: Jung, Yun Ji, Cho, Hee Young, Cho, SiHyun, Kim, Young Han, Jeon, Jin-Dong, Kim, Young-Jin, Lee, Sanghoo, Park, Jimyeong, Kim, Ha Yan, Park, Yong-Won, Kwon, Ja-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290021/
https://www.ncbi.nlm.nih.gov/pubmed/28120572
http://dx.doi.org/10.3349/ymj.2017.58.2.401
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author Jung, Yun Ji
Cho, Hee Young
Cho, SiHyun
Kim, Young Han
Jeon, Jin-Dong
Kim, Young-Jin
Lee, Sanghoo
Park, Jimyeong
Kim, Ha Yan
Park, Yong-Won
Kwon, Ja-Young
author_facet Jung, Yun Ji
Cho, Hee Young
Cho, SiHyun
Kim, Young Han
Jeon, Jin-Dong
Kim, Young-Jin
Lee, Sanghoo
Park, Jimyeong
Kim, Ha Yan
Park, Yong-Won
Kwon, Ja-Young
author_sort Jung, Yun Ji
collection PubMed
description PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34(+4) weeks (range 29(+5)–36(+6)). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE.
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spelling pubmed-52900212017-03-01 The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia Jung, Yun Ji Cho, Hee Young Cho, SiHyun Kim, Young Han Jeon, Jin-Dong Kim, Young-Jin Lee, Sanghoo Park, Jimyeong Kim, Ha Yan Park, Yong-Won Kwon, Ja-Young Yonsei Med J Original Article PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34(+4) weeks (range 29(+5)–36(+6)). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE. Yonsei University College of Medicine 2017-03-01 2017-01-16 /pmc/articles/PMC5290021/ /pubmed/28120572 http://dx.doi.org/10.3349/ymj.2017.58.2.401 Text en © Copyright: Yonsei University College of Medicine 2017 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Yun Ji
Cho, Hee Young
Cho, SiHyun
Kim, Young Han
Jeon, Jin-Dong
Kim, Young-Jin
Lee, Sanghoo
Park, Jimyeong
Kim, Ha Yan
Park, Yong-Won
Kwon, Ja-Young
The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
title The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
title_full The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
title_fullStr The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
title_full_unstemmed The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
title_short The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
title_sort level of serum and urinary nephrin in normal pregnancy and pregnancy with subsequent preeclampsia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290021/
https://www.ncbi.nlm.nih.gov/pubmed/28120572
http://dx.doi.org/10.3349/ymj.2017.58.2.401
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