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The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia
PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnanc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Yonsei University College of Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290021/ https://www.ncbi.nlm.nih.gov/pubmed/28120572 http://dx.doi.org/10.3349/ymj.2017.58.2.401 |
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author | Jung, Yun Ji Cho, Hee Young Cho, SiHyun Kim, Young Han Jeon, Jin-Dong Kim, Young-Jin Lee, Sanghoo Park, Jimyeong Kim, Ha Yan Park, Yong-Won Kwon, Ja-Young |
author_facet | Jung, Yun Ji Cho, Hee Young Cho, SiHyun Kim, Young Han Jeon, Jin-Dong Kim, Young-Jin Lee, Sanghoo Park, Jimyeong Kim, Ha Yan Park, Yong-Won Kwon, Ja-Young |
author_sort | Jung, Yun Ji |
collection | PubMed |
description | PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34(+4) weeks (range 29(+5)–36(+6)). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE. |
format | Online Article Text |
id | pubmed-5290021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-52900212017-03-01 The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia Jung, Yun Ji Cho, Hee Young Cho, SiHyun Kim, Young Han Jeon, Jin-Dong Kim, Young-Jin Lee, Sanghoo Park, Jimyeong Kim, Ha Yan Park, Yong-Won Kwon, Ja-Young Yonsei Med J Original Article PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34(+4) weeks (range 29(+5)–36(+6)). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE. Yonsei University College of Medicine 2017-03-01 2017-01-16 /pmc/articles/PMC5290021/ /pubmed/28120572 http://dx.doi.org/10.3349/ymj.2017.58.2.401 Text en © Copyright: Yonsei University College of Medicine 2017 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jung, Yun Ji Cho, Hee Young Cho, SiHyun Kim, Young Han Jeon, Jin-Dong Kim, Young-Jin Lee, Sanghoo Park, Jimyeong Kim, Ha Yan Park, Yong-Won Kwon, Ja-Young The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |
title | The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |
title_full | The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |
title_fullStr | The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |
title_full_unstemmed | The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |
title_short | The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia |
title_sort | level of serum and urinary nephrin in normal pregnancy and pregnancy with subsequent preeclampsia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290021/ https://www.ncbi.nlm.nih.gov/pubmed/28120572 http://dx.doi.org/10.3349/ymj.2017.58.2.401 |
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