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Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero

PURPOSE: Infants on prolonged breastfeeding are known to grow slower during the first year of life. It is still unclear if such effects are similar in offspring exposed to gestational diabetes (GDM) in utero. We examined the associations of infant milk feeding on postnatal growth from birth till 36 ...

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Autores principales: Aris, Izzuddin M., Soh, Shu E., Tint, Mya Thway, Saw, Seang Mei, Rajadurai, Victor S., Godfrey, Keith M., Gluckman, Peter D., Yap, Fabian, Chong, Yap Seng, Lee, Yung Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290064/
https://www.ncbi.nlm.nih.gov/pubmed/26415764
http://dx.doi.org/10.1007/s00394-015-1057-0
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author Aris, Izzuddin M.
Soh, Shu E.
Tint, Mya Thway
Saw, Seang Mei
Rajadurai, Victor S.
Godfrey, Keith M.
Gluckman, Peter D.
Yap, Fabian
Chong, Yap Seng
Lee, Yung Seng
author_facet Aris, Izzuddin M.
Soh, Shu E.
Tint, Mya Thway
Saw, Seang Mei
Rajadurai, Victor S.
Godfrey, Keith M.
Gluckman, Peter D.
Yap, Fabian
Chong, Yap Seng
Lee, Yung Seng
author_sort Aris, Izzuddin M.
collection PubMed
description PURPOSE: Infants on prolonged breastfeeding are known to grow slower during the first year of life. It is still unclear if such effects are similar in offspring exposed to gestational diabetes (GDM) in utero. We examined the associations of infant milk feeding on postnatal growth from birth till 36 months of age in offspring exposed and unexposed to GDM. METHODS: Pregnant mothers undertook 75 g 2-h oral glucose tolerance tests at 26–28 weeks of gestation for GDM diagnosis. Up to 9 measurements of offspring weight and length were collected from birth till 36 months, and interviewer-administered questionnaires were used to ascertain the duration of breastfeeding. RESULTS: There was a statistically significant interaction between GDM status and breastmilk intake by any (p (interaction) = 0.038) or exclusive/predominant breastfeeding (p (interaction) = 0.035) for the outcome of conditional weight gain. In offspring of non-GDM mothers (n = 835), greater breastmilk intake (BF ≥ 4 milk months) was associated with lower conditional gains in weight [B (95 % CI) −0.48 (−0.58, −0.28); p < 0.001] within the first year of life, as well as decreasing weight SDS velocity [−0.01 (−0.02, −0.005); p < 0.001] and BMI SDS velocity [−0.008 (0.01, −0.002); p = 0.008] across age in the first 36 months. In offspring of GDM mothers (n = 181), however, greater breastmilk intake was associated with increased conditional gains in weight [0.72 (0.23, 1.20); p = 0.029] and BMI SDS [0.49 (0.04, 0.95); p = 0.04] in the first 6 months and did not demonstrate the decreasing weight and BMI SDS velocity observed in offspring of non-GDM mothers. CONCLUSIONS: The reduced weight gain in the first year of life conferred by greater breastmilk intake in non-GDM children was not observed in GDM children. CLINICAL TRIAL REGISTRATION: This study is registered under the Clinical Trials identifier NCT01174875; http://www.clinicaltrials.gov/ct2/show/NCT01174875?term=GUSTO&rank=2. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00394-015-1057-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-52900642017-02-16 Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero Aris, Izzuddin M. Soh, Shu E. Tint, Mya Thway Saw, Seang Mei Rajadurai, Victor S. Godfrey, Keith M. Gluckman, Peter D. Yap, Fabian Chong, Yap Seng Lee, Yung Seng Eur J Nutr Original Contribution PURPOSE: Infants on prolonged breastfeeding are known to grow slower during the first year of life. It is still unclear if such effects are similar in offspring exposed to gestational diabetes (GDM) in utero. We examined the associations of infant milk feeding on postnatal growth from birth till 36 months of age in offspring exposed and unexposed to GDM. METHODS: Pregnant mothers undertook 75 g 2-h oral glucose tolerance tests at 26–28 weeks of gestation for GDM diagnosis. Up to 9 measurements of offspring weight and length were collected from birth till 36 months, and interviewer-administered questionnaires were used to ascertain the duration of breastfeeding. RESULTS: There was a statistically significant interaction between GDM status and breastmilk intake by any (p (interaction) = 0.038) or exclusive/predominant breastfeeding (p (interaction) = 0.035) for the outcome of conditional weight gain. In offspring of non-GDM mothers (n = 835), greater breastmilk intake (BF ≥ 4 milk months) was associated with lower conditional gains in weight [B (95 % CI) −0.48 (−0.58, −0.28); p < 0.001] within the first year of life, as well as decreasing weight SDS velocity [−0.01 (−0.02, −0.005); p < 0.001] and BMI SDS velocity [−0.008 (0.01, −0.002); p = 0.008] across age in the first 36 months. In offspring of GDM mothers (n = 181), however, greater breastmilk intake was associated with increased conditional gains in weight [0.72 (0.23, 1.20); p = 0.029] and BMI SDS [0.49 (0.04, 0.95); p = 0.04] in the first 6 months and did not demonstrate the decreasing weight and BMI SDS velocity observed in offspring of non-GDM mothers. CONCLUSIONS: The reduced weight gain in the first year of life conferred by greater breastmilk intake in non-GDM children was not observed in GDM children. CLINICAL TRIAL REGISTRATION: This study is registered under the Clinical Trials identifier NCT01174875; http://www.clinicaltrials.gov/ct2/show/NCT01174875?term=GUSTO&rank=2. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00394-015-1057-0) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-09-28 2017 /pmc/articles/PMC5290064/ /pubmed/26415764 http://dx.doi.org/10.1007/s00394-015-1057-0 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Contribution
Aris, Izzuddin M.
Soh, Shu E.
Tint, Mya Thway
Saw, Seang Mei
Rajadurai, Victor S.
Godfrey, Keith M.
Gluckman, Peter D.
Yap, Fabian
Chong, Yap Seng
Lee, Yung Seng
Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
title Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
title_full Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
title_fullStr Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
title_full_unstemmed Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
title_short Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
title_sort associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290064/
https://www.ncbi.nlm.nih.gov/pubmed/26415764
http://dx.doi.org/10.1007/s00394-015-1057-0
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